Nayak Shivananda B, Maharaj Nalini, Fatt Le-Ann Lue
Department of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad and Tobago.
Indian J Med Sci. 2012 Sep-Oct;66(9-10):214-21.
The obesity and hypertension have become the causes for the development type 2 diabetes. There is a limited study done on the contribution of body mass index (BMI) to blood pressure (BP) in the Caribbean population. Aim of our study was to determine the associations between lipid profile, BMI, adiponectin, and BP in Trinidadian type 2 diabetic patients with regards to age and ethnicity.
This was a cohort study comprised of 266 subjects (85 males and 181 females) attending primary and tertiary healthcare settings in central Trinidad. Of which, 126 diabetic subjects were matched with 140 non-diabetic subjects. Along with clinical history and anthropometry, adiponectin and lipid profile were measured in fasting blood samples.
The diabetic group had higher triglycerides, very low density lipoprotein (VLDL), and BP values which were statistically significant (P < 0.05) when compared to non-diabetic subjects. The high-density lipoprotein cholesterol (HDL-c) and adiponectin were lower in diabetic subjects. HDL-c showed significant changes for ethnicity (P = 0.013) and gender (P = 0.043). The mean adiponectin concentrations were found to be significantly different among the ethnic groups (P = 0.001). Systolic pressure varied significantly with age (P = 0.018). As age increased, BP also increased. Ethnic groups had a significant difference in diastolic pressure (P = 0.027). East Indians had the highest mean diastolic pressure (80.74 ± 10.29) when compared to all other ethnic groups.
HDL-cholesterol, low levels of adiponectin, and varied BP are associated in Trinidadian type 2 diabetic subjects with regards to age, gender, and ethnicity.
肥胖和高血压已成为2型糖尿病发病的原因。关于加勒比人群中体重指数（BMI）对血压（BP）的影响的研究有限。我们研究的目的是确定特立尼达2型糖尿病患者中血脂谱、BMI、脂联素和BP之间在年龄和种族方面的关联。
这是一项队列研究，由266名受试者（85名男性和181名女性）组成，他们在特立尼达中部的初级和三级医疗机构就诊。其中，126名糖尿病受试者与140名非糖尿病受试者相匹配。除了临床病史和人体测量学外，还在空腹血样中测量了脂联素和血脂谱。
与非糖尿病受试者相比，糖尿病组的甘油三酯、极低密度脂蛋白（VLDL）和BP值更高，具有统计学意义（P < 0.05）。糖尿病受试者的高密度脂蛋白胆固醇（HDL-c）和脂联素较低。HDL-c在种族（P = 0.013）和性别（P = 0.043）方面有显著变化。发现不同种族之间的平均脂联素浓度有显著差异（P = 0.001）。收缩压随年龄有显著变化（P = 0.018）。随着年龄的增加，BP也升高。不同种族在舒张压方面有显著差异（P = 0.027）。与所有其他种族相比，东印度人的平均舒张压最高（80.74 ± 10.29）。
在特立尼达2型糖尿病受试者中，HDL胆固醇、低水平脂联素和不同的BP在年龄、性别和种族方面存在关联。
