Terashima T, Ohtake K, Ogawa T
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Am J Hematol. 1990 Sep;35(1):56-8. doi: 10.1002/ajh.2830350112.
The patient was a 65 year old woman with a massive splenomegaly and no lymphoadenopathy. An electron microscopic study of the peripheral blood cells revealed that these cells were prolymphocytes with a single large nucleolus. Treatment with native and recombinant alpha-interferon has produced an impressive reduction in spleen size and in the count of prolymphocytes.
该患者为一名65岁女性，有巨大脾肿大但无淋巴结病。对外周血细胞进行的电子显微镜研究显示，这些细胞是带有单个大核仁的原淋巴细胞。使用天然和重组α-干扰素进行治疗后，脾脏大小和原淋巴细胞计数显著降低。
