Eusebi V, Bondi A, Cancellieri A, Canedi L, Frizzera G
Istituto di Anatomia e Istologia Patologica, Università degli Studi di Bologna, Italy.
Am J Surg Pathol. 1990 Sep;14(9):881-5. doi: 10.1097/00000478-199009000-00011.
A 72-year-old man with a 2-year history of motor-sensory neuropathy of the right foot was found to have a lymphoma involving a 50-cm length of the sciatic nerve. This occurred in the absence of any other evidence of disease by detailed clinical staging. The lymphoma was of large follicular center-cell type. The cells strongly expressed a B-cell marker detected by the 4KB5 monoclonal antibody and selectively infiltrated the nerve bundles, dissociating preexisting myelin-producing Schwann cells and axons. This is the second report of similar localization. Primary selective involvement of a nerve is a rare mechanism of peripheral neuropathy in lymphoproliferative disorders, to be added to systemic dissemination of lymphomas and leukemias, direct spread of an adjacent tumor, and immunologically mediated disease.
一名72岁男性，有2年右足运动感觉神经病变病史，经检查发现患有淋巴瘤，累及坐骨神经长度达50厘米。详细的临床分期未发现任何其他疾病证据。该淋巴瘤为大滤泡中心细胞型。细胞强烈表达由4KB5单克隆抗体检测到的B细胞标志物，并选择性浸润神经束，使先前产生髓鞘的施万细胞和轴突分离。这是类似定位的第二例报告。神经的原发性选择性受累是淋巴增殖性疾病中周围神经病变的一种罕见机制，此外还有淋巴瘤和白血病的全身播散、邻近肿瘤的直接蔓延以及免疫介导性疾病。
