Purohit D P, Dick D J, Perry R H, Lyons P R, Schofield I S, Foster J B
J Neurol Sci. 1986 Jun;74(1):23-34. doi: 10.1016/0022-510x(86)90188-7.
A solitary extranodal malignant lymphoma (non-Hodgkin's lymphoma, centrocytic type) of the sciatic nerve is described in a 64-year-old woman. Whereas previous reports of peripheral nervous system lymphoma have described multifocal lesions and generally an association with systemic lymphomas, in this case the lymphoma was confined to a segment of a peripheral nerve and was not associated with systemic lymphoma. The clinical presentation was a progressive weakness and sensory disturbance in the right leg. Clinical and electrophysiological examination indicated a lesion in the sciatic nerve, and computerised tomography of the right thigh revealed an enlarged distal segment of the sciatic nerve. On surgical exploration, a fusiform tumour of the sciatic nerve was resected. Pathological examination, including immunohistology and electron microscopy revealed a malignant lymphoma. An unusual histological feature was the presence in the tumour and infiltrated nerve of an extracellular eosinophilic non-amyloid material, similar to that occasionally seen in nodal lymphomas. The patient showed no evidence of lymphoma at other sites at the presentation and this has been confirmed at a 9-month review.
本文描述了一名64岁女性患者，其坐骨神经出现孤立性结外恶性淋巴瘤（非霍奇金淋巴瘤，中心细胞型）。既往关于周围神经系统淋巴瘤的报道多描述为多灶性病变，且通常与系统性淋巴瘤相关，而该病例中的淋巴瘤局限于一段周围神经，与系统性淋巴瘤无关。临床表现为右下肢进行性无力和感觉障碍。临床及电生理检查提示坐骨神经病变，右大腿计算机断层扫描显示坐骨神经远端增粗。手术探查时，切除了坐骨神经的梭形肿瘤。病理检查，包括免疫组织学和电子显微镜检查，显示为恶性淋巴瘤。一个不寻常的组织学特征是肿瘤及浸润神经中存在细胞外嗜酸性非淀粉样物质，类似于在淋巴结淋巴瘤中偶尔见到的物质。该患者初诊时其他部位未发现淋巴瘤证据，9个月复查时得以证实。
