McGill Centre for Studies in Aging, 6825 Lasalle Blvd, Verdun, QC H4H 1R3, Canada.
Expert Rev Gastroenterol Hepatol. 2013 Jul;7(5):413-9. doi: 10.1586/17474124.2013.811043.
A multidisciplinary analysis restricted to validated reports was applied to the cause and management of irritable bowel syndrome and diverticular formation and subsequent diverticulitis. There is evidence that they are linked - both caused by attenuation of gravitational aid to distal intestinal motility, resulting in damaging chronic intestinal distention. Both irritable bowel syndrome and diverticular formation and subsequent diverticulitis have worsened in recent years owing to excessive dietary fiber intake. Potential solutions include augmenting weight-bearing time, moderating dietary fiber consumption, stimulating distal colon evacuation through chemical means and developing pharmaceuticals to block the reflexive distal colon distention associated with fiber consumption. Amplified intestinal distention commenced when all classes of Renaissance Europeans became the first group in human history to wear shoes, which led to a sedentary lifestyle that moderates gravitational aid to colon motility and evacuation.
采用多学科分析方法,仅限于已验证的报告,研究肠易激综合征和憩室形成以及随后的憩室炎的病因和治疗。有证据表明它们是相关的——两者都由远端肠道运动的重力辅助减弱引起,导致慢性肠道膨胀损伤。近年来,由于膳食纤维摄入过多,肠易激综合征、憩室形成和随后的憩室炎都有所恶化。潜在的解决方案包括增加承重时间、适度膳食纤维摄入、通过化学手段刺激远端结肠排空以及开发药物来阻断与纤维摄入相关的反射性远端结肠膨胀。当所有类别的文艺复兴时期欧洲人成为人类历史上第一组穿鞋的人时,肠道膨胀加剧开始了,这导致了久坐的生活方式,减缓了重力对结肠运动和排空的辅助作用。