Uzuka Y, Saito Y
Third Dept. of Internal Medicine, Tohoku University, School of Medicine, Sendai.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 1):1473-80.
The objective of the current study is to clarify the concept and to demonstrate the encouraging results of individualized chemotherapy for adult acute nonlymphocytic leukemia. Settlement of target point for remission induction and individual adjustment of the treatment schedules according to response to therapy is fundamental for the treatment strategy. Since 1982, 37 consecutive adults with newly diagnosed acute nonlymphocytic leukemia were treated with individualized chemotherapy using intensive DCMP sequential multi-step therapy. Eighty-four percent of patients entered CR. Actuarial remission duration at greater than 4 years was 63.4 +/- 10.2% (95% confidence interval).
本研究的目的是阐明成人急性非淋巴细胞白血病个体化化疗的概念，并展示其令人鼓舞的结果。确定缓解诱导的靶点以及根据治疗反应对治疗方案进行个体化调整是治疗策略的基础。自1982年以来，37例新诊断的成人急性非淋巴细胞白血病患者采用强化DCMP序贯多步疗法进行个体化化疗。84%的患者进入完全缓解（CR）状态。4年以上的精算缓解持续时间为63.4±10.2%（95%置信区间）。
