Sasaki A, Tsukaguchi M
Department of Internal Medicine, Sakai Municipal Hospital, Japan.
Gan To Kagaku Ryoho. 1992 Aug;19(9):1303-7.
We made a retrospective study of 44 patients with acute non-lymphocytic leukemia (ANLL) and 14 patients with acute lymphocytic leukemia (ALL) admitted to our hospital from September 1984 to May 1991. The complete remission (CR) rate of ANLL was 90.9%, against 85.7% for ALL. The 5-year survival of ANLL was 50.7%, and that of ANLL under age 60 years was 70.3%. The 2-year median survival of ALL was 35.1%. These results were obtained with response-oriented individualized therapy, and intensive chemotherapy with a view to eradication of residual leukemic cells. Eight elderly patients with ANLL were treated with cytosine arabinoside in low doses. Complete remission was achieved in 6 patients, but these cases relapsed. These treatments should be reconsidered for long CR duration. Our schedules of response-oriented individualized therapy were too flexible to apply at another institute so they should be arranged for general application.
我们对1984年9月至1991年5月期间收治于我院的44例急性非淋巴细胞白血病（ANLL）患者和14例急性淋巴细胞白血病（ALL）患者进行了回顾性研究。ANLL的完全缓解（CR）率为90.9%，ALL为85.7%。ANLL的5年生存率为50.7%，60岁以下ANLL患者的5年生存率为70.3%。ALL的2年中位生存期为35.1%。这些结果是通过以反应为导向的个体化治疗以及旨在根除残留白血病细胞的强化化疗获得的。8例老年ANLL患者接受了小剂量阿糖胞苷治疗。6例患者实现了完全缓解，但这些病例均复发。对于获得长期CR，这些治疗方法应重新考虑。我们以反应为导向的个体化治疗方案过于灵活，难以在其他机构应用，因此应安排使其能够普遍应用。
