Kokura S, Yoshikawa T, Kishi A, Tomii T, Tsujigiwa M, Yasuda M, Ichikawa H, Takano H, Takahashi S, Naito Y
First Dept. of Medicine, Kyoto Prefectural University of Medicine.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1711-4.
This study examined the role of oxygen-derived free radicals for antitumor effects of intra-arterial injection with adriamycin (ADR). The effect of chemoembolization using ADR and degradable starch microspheres (DSM) was studied in rabbits with VX2 carcinoma of the hind leg. The tumor growth in rabbit treated with chemoembolization (ADR: 3.0 mg/kg + DSM 20mg/kg) was completely suppressed, but the therapeutic effect of chemoembolization combined with dimethylsulfoxide (DMSO) was reduced. On the other hand, the therapeutic effect of chemoembolization combined with superoxide dismutase and catalase was not reduced. These results indicate that the production of oxygen-derived free radicals, especially hydroxyl radical in the cancer cell, plays an important role in the antitumor effect of adriamycin.
本研究探讨了氧衍生自由基在阿霉素（ADR）动脉内注射抗肿瘤作用中的作用。在患有后肢VX2癌的兔中研究了使用ADR和可降解淀粉微球（DSM）进行化疗栓塞的效果。用化疗栓塞（ADR：3.0mg/kg + DSM 20mg/kg）治疗的兔的肿瘤生长被完全抑制，但化疗栓塞联合二甲基亚砜（DMSO）的治疗效果降低。另一方面，化疗栓塞联合超氧化物歧化酶和过氧化氢酶的治疗效果未降低。这些结果表明，氧衍生自由基尤其是癌细胞中羟基自由基的产生在阿霉素的抗肿瘤作用中起重要作用。
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