Yoshikawa T, Itani K, Kokura S, Oyamada H, Kondo M
1st Dept. of Internal Medicine, Kyoto Prefectural University of Medicine.
Gan To Kagaku Ryoho. 1993 Sep;20(12):1803-9.
We investigated the anticancer effect and pharmacokinetics of doxorubicin hydrochloride(ADR, 1 mg/kg) and mitomycin C (MMC, 0.2 mg/kg) given intra-arterially in combination with a temporary embolizing material, degradable starch microspheres (DSM, 5 mg/kg), to rabbits in which VX2 tumors had been implanted into the liver. The results revealed that the anticancer effect of ADR and MMC was potentiated by concomitant treatment with DSM in comparison to intra-arterial drug therapy alone. The tumor growth inhibition rate in both groups was about 87%. There was a tendency of higher intra-tumour ADR concentrations after ADR and DSM than after ADR alone. When we measured the serum levels of ADR and MMC over 45 min., it was indicated that exposure of the drugs to the systemic circulation was inhibited by the combination with DSM. In these experiments, GOT and GPT values increased temporarily after intra-arterial chemotherapy combined with DSM, but decreased gradually later to normal or close to the normal levels. These results indicate that intra-arterial chemotherapy combined with DSM causes a temporary blood flow blockade and the resulting regional retention of the cytotoxic agents, provides a more potent anticancer effect than drug therapy alone.
我们研究了盐酸阿霉素（ADR，1毫克/千克）和丝裂霉素C（MMC，0.2毫克/千克）经动脉内给药，并联合一种临时栓塞材料——可降解淀粉微球（DSM，5毫克/千克），对已在肝脏植入VX2肿瘤的家兔的抗癌效果和药代动力学。结果显示，与单纯动脉内药物治疗相比，ADR和MMC联合DSM治疗可增强抗癌效果。两组的肿瘤生长抑制率均约为87%。ADR与DSM联合给药后肿瘤内ADR浓度有高于单纯ADR给药后的趋势。当我们在45分钟内测定ADR和MMC的血清水平时，结果表明与DSM联合使用可抑制药物进入体循环。在这些实验中，动脉内化疗联合DSM后谷草转氨酶（GOT）和谷丙转氨酶（GPT）值暂时升高，但随后逐渐下降至正常或接近正常水平。这些结果表明，动脉内化疗联合DSM会导致暂时的血流阻断以及由此产生的细胞毒性药物在局部的潴留，比单纯药物治疗具有更强的抗癌效果。
