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本文引用的文献

1
Performance of Clostridium difficile toxin enzyme immunoassay and nucleic acid amplification tests stratified by patient disease severity.按患者疾病严重程度分层的艰难梭菌毒素酶免疫分析和核酸扩增检测的性能。
J Clin Microbiol. 2013 Mar;51(3):869-73. doi: 10.1128/JCM.02970-12. Epub 2012 Dec 26.
2
Clinical impact of switching conventional enzyme immunoassay with nucleic acid amplification test for suspected Clostridium difficile-associated diarrhea.疑似艰难梭菌相关性腹泻时，用核酸扩增试验替代传统酶免疫分析法的临床影响。
Am J Infect Control. 2013 Apr;41(4):373-5. doi: 10.1016/j.ajic.2012.04.329. Epub 2012 Oct 5.
3
Impact of the type of diagnostic assay on Clostridium difficile infection and complication rates in a mandatory reporting program.诊断检测类型对强制性报告程序中艰难梭菌感染和并发症发生率的影响。
Clin Infect Dis. 2013 Jan;56(1):67-73. doi: 10.1093/cid/cis840. Epub 2012 Sep 25.
4
Improved detection of toxigenic Clostridium difficile using the Cepheid Xpert C difficile assay and impact on C difficile infection rates in a tertiary hospital: a double-edged sword.采用赛沛 Xpert C difficile 检测法提高产毒艰难梭菌的检出率及其对三级医院艰难梭菌感染率的影响：一把双刃剑。
Am J Infect Control. 2013 Mar;41(3):270-2. doi: 10.1016/j.ajic.2012.03.025. Epub 2012 Aug 30.
5
Molecular techniques for diagnosis of Clostridium difficile infection: systematic review and meta-analysis.分子技术在艰难梭菌感染诊断中的应用：系统评价和荟萃分析。
Mayo Clin Proc. 2012 Jul;87(7):643-51. doi: 10.1016/j.mayocp.2012.02.024.
6
Diagnosis of Clostridium difficile infection.
Clin Infect Dis. 2012 Jun;54(11):1675-6. doi: 10.1093/cid/cis259. Epub 2012 Apr 13.
7
Vital signs: preventing Clostridium difficile infections.生命体征：预防艰难梭菌感染。
MMWR Morb Mortal Wkly Rep. 2012 Mar 9;61(9):157-62.
8
Clinical and laboratory evaluation of a real-time PCR for Clostridium difficile toxin A and B genes.实时 PCR 检测艰难梭菌毒素 A 和 B 基因的临床和实验室评估。
Eur J Clin Microbiol Infect Dis. 2012 Sep;31(9):2219-25. doi: 10.1007/s10096-012-1558-1. Epub 2012 Feb 14.
9
Loop-mediated isothermal amplification compared to real-time PCR and enzyme immunoassay for toxigenic Clostridium difficile detection.环介导等温扩增与实时 PCR 和酶免疫分析检测产毒艰难梭菌的比较。
J Clin Microbiol. 2012 Mar;50(3):640-5. doi: 10.1128/JCM.01014-11. Epub 2011 Dec 21.
10
Public reporting of Clostridium difficile and improvements in diagnostic tests.艰难梭菌的公开报告及诊断测试的改进
Infect Control Hosp Epidemiol. 2011 Dec;32(12):1231-2; author reply 1233. doi: 10.1086/663014.

核酸扩增检测对基于人群的艰难梭菌感染发病率的影响。

Effect of nucleic acid amplification testing on population-based incidence rates of Clostridium difficile infection.

机构信息

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention.

出版信息

Clin Infect Dis. 2013 Nov;57(9):1304-7. doi: 10.1093/cid/cit492. Epub 2013 Jul 29.

DOI:10.1093/cid/cit492
PMID:23899677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9580544/
Abstract

Nucleic acid amplification testing (NAAT) is increasingly being adopted for diagnosis of Clostridium difficile infection (CDI). Data from 3 states conducting population-based CDI surveillance showed increases ranging from 43% to 67% in CDI incidence attributable to changing from toxin enzyme immunoassays to NAAT. CDI surveillance requires adjustment for testing methods.

摘要

核酸扩增检测（NAAT）越来越多地被用于诊断艰难梭菌感染（CDI）。来自 3 个州进行的基于人群的 CDI 监测的数据显示，由于将毒素酶免疫测定法改为 NAAT，归因于 CDI 发病率的增加幅度从 43%到 67%不等。CDI 监测需要针对检测方法进行调整。