Improved motility of retrograde ejaculates by adding donor seminal plasma.

Poor quality sperm motility might, in some instances, be related to a defect in the seminal fluid rather than in an intrinsic sperm defect. Three men with sperm lacking progressive forward motion (PFM), 40 min after suspension of their small antegrade fraction of a retrograde ejaculation in Ham's F-10 medium, did demonstrate sperm with PFM after suspension of the sperm in donor seminal plasma (DSP). All three achieved pregnancies following the intracervical insemination of their wives within a total of nine ovulatory cycles. Further investigation is needed to determine if the use of DSP can be applied to improve sperm motility in infertile males with a asthenozoospermia but without the complications of retrograde ejaculation. Suspension of sperm in donor seminal plasma had an enhanced effect on asthenozoospermia compared to Ham's F-10 medium in three infertile males with retrograde ejaculation and enabled them to impregnate their wives.