de Lamirande E, Sherins R J, Gagnon C
J Androl. 1986 Jul-Aug;7(4):215-9. doi: 10.1002/j.1939-4640.1986.tb00916.x.
The presence of motility inhibitors in seminal plasma and within spermatozoa from control and infertile men with poor sperm motility was investigated using demembranated reactivated human spermatozoa. No difference was found in the inhibitory capacities in seminal plasma of patients with poor sperm motility (less than 50%) when compared with that of fertile controls with motility above 50%. No correlation was observed between inhibitory capacity and sperm motility. However, when extracts of spermatozoa from these patients were tested for the presence of inhibitor, it was observed that three of nine patients had an inhibitor in their sperm extract. By contrast, all sperm extracts from fertile control subjects were devoid of inhibitor. It was concluded that the presence of a motility inhibitor in seminal plasma does not explain the poor sperm motility observed in patients. The presence of a motility inhibitor within spermatozoa, however, may represent an important factor in the etiology of the poor sperm motility observed in some patients.
利用去膜再活化的人类精子，研究了来自精子活力差的对照男性和不育男性的精浆及精子内运动抑制剂的存在情况。精子活力差（低于50%）的患者精浆的抑制能力与精子活力高于50%的生育对照者相比，未发现差异。未观察到抑制能力与精子活力之间存在相关性。然而，当检测这些患者精子提取物中抑制剂的存在时，发现9名患者中有3名的精子提取物中存在抑制剂。相比之下，生育对照受试者的所有精子提取物均无抑制剂。得出的结论是，精浆中存在运动抑制剂并不能解释患者中观察到的精子活力差的情况。然而，精子内存在运动抑制剂可能是一些患者中观察到的精子活力差病因的一个重要因素。
