Dahlberg B
Department of Obstetrics and Gynecology, University of Lund, General Hospital, Malmö, Sweden.
Arch Androl. 1990;25(1):85-7. doi: 10.3109/01485019008987598.
Abnormal spermiograms with asthenozoospermia and teratozoospermia are often classified as subfertile, and the cause of these findings has been obscure. A new method, the 8-h in vitro motility profile test (MPT), showed a significant difference in motility profile between 130 fertile men and men of infertile couples. In the infertile group, an infertility factor (IF) was found. The method was applied to 133 cases, group A, with asthenozoospermia and teratozoospermia. Microbial cultures of semen were also done. Controls, group B, which were 52 males with asthenozoospermia and teratozoospermia, were also investigated with MPT and microbial cultures. All 133 cases of group A had abnormal MPT indicating infertility factor. One hundred and twenty-six cases had positive microbial findings (95%). Long-term treatment with antibiotics of the 126 normalized motility and morphology and eradicated microbes. The MPT was, however, only normalized in 5 cases with two men becoming fathers. The infertility factor, according to the MPT, remained in 128 cases. Though treatment of bacteriospermia has an apparent normalization of parameters as motility, morphology, and cultures, an underlying infertility factor remains in cases of asthenozoospermia and teratozoospermia.
伴有弱精子症和畸形精子症的异常精子图谱通常被归类为亚生育能力，而这些结果的原因一直不明。一种新方法，即8小时体外运动特征测试（MPT），显示130名有生育能力的男性与不育夫妇中的男性在运动特征上存在显著差异。在不育组中，发现了一个不育因素（IF）。该方法应用于133例A组患有弱精子症和畸形精子症的患者。同时也对精液进行了微生物培养。对照组B组为52名患有弱精子症和畸形精子症的男性，也采用MPT和微生物培养进行了研究。A组的所有133例患者MPT均异常，表明存在不育因素。126例微生物检测结果呈阳性（95%）。对这126例患者长期使用抗生素治疗后，精子活力和形态恢复正常，微生物被清除。然而，只有5例患者的MPT恢复正常，其中两名男性成功使配偶受孕。根据MPT检测，仍有128例存在不育因素。虽然治疗细菌性精液症后，精子活力、形态和培养等参数明显恢复正常，但在弱精子症和畸形精子症病例中，潜在的不育因素仍然存在。
