Sydow G, Sydow H
Zentralinstitut für Krebsforschung, Akademie der Wissenschaften der DDR, Robert-Rössle-Institut, Berlin-Buch.
Arch Geschwulstforsch. 1990;60(4):279-82.
A single application of trypan blue 3 to 24 hours before or simultaneous with inoculation of the Rauscher leukemia virus (RLV) resulted in enhancement of leukemogenesis with an especially high viremia. Repeated administration of trypan blue after RLV infection resulted in reduced spleen weight. Viremia, however, was also increased compared with controls (no application of trypan blue), but in a lower rate than in mice treated with the virus plus trypan blue. Since trypan blue is known as an inhibitor of the functions of macrophages the results point at an important role of this cell type in preventing infection with this oncogenic retrovirus. In this regard there are differences in the role of macrophages in human immunodeficiency virus (HIV) infections.
在接种劳氏肉瘤病毒（RLV）前3至24小时单次应用台盼蓝或与接种同时应用台盼蓝，会导致白血病发生增强，伴有特别高的病毒血症。RLV感染后重复给予台盼蓝会导致脾脏重量减轻。然而，与对照组（未应用台盼蓝）相比，病毒血症也有所增加，但增加速率低于病毒加台盼蓝处理的小鼠。由于台盼蓝是已知的巨噬细胞功能抑制剂，这些结果表明这种细胞类型在预防这种致癌逆转录病毒感染中起重要作用。在这方面，巨噬细胞在人类免疫缺陷病毒（HIV）感染中的作用存在差异。
