银屑病患者的心率恢复受损。
Heart rate recovery is impaired in patients with psoriasis.
机构信息
Department of Cardiology, Kayseri Education and Research Hospital, Kayseri, Turkey.
出版信息
Med Princ Pract. 2013;22(6):567-70. doi: 10.1159/000351884. Epub 2013 Jul 26.
OBJECTIVE
The aim of this study was to investigate the relationship between psoriasis and heart rate recovery (HRR) index.
PATIENTS AND METHODS
A total of 50 patients with a diagnosis of psoriasis and 32 healthy volunteers were included in the study. In all patients, a stress test was performed to calculate the HRR index in a manner which aimed to reach the age-specific maximum heart rate. HRR indices were calculated in all patients and controls.
RESULTS
HRR (beats/minute) indices after the 1st (HRR1, 26 ± 10 vs. 33 ± 8, p = 0.002), 2nd (44 ± 11 vs. 50 ± 6, p = 0.002), 3rd (51 ± 7 vs. 63 ± 8, p < 0.001), 4th (54 ± 7 vs. 65 ± 8, p < 0.001) and 5th (57 ± 8 vs. 70 ± 10, p < 0.001) minutes of the recovery period were significantly lower in the psoriasis group compared to healthy controls. In addition, HRR1 was significantly correlated with duration of psoriasis (r = 0.541, p < 0.001) and psoriasis area and severity index score (r = 0.511, p < 0.001).
CONCLUSION
HRR was lower in patients with psoriasis. Given the prognostic value of this test, patients with psoriasis might be at risk for future cardiovascular events and cardiovascular mortality.
目的
本研究旨在探讨银屑病与心率恢复（HRR）指数之间的关系。
患者和方法
本研究纳入了 50 名确诊为银屑病的患者和 32 名健康志愿者。所有患者均进行了压力测试，以计算达到年龄特异性最大心率的 HRR 指数。在所有患者和对照组中计算了 HRR 指数。
结果
银屑病组患者在恢复的第 1 分钟（HRR1，26 ± 10 比 33 ± 8，p = 0.002）、第 2 分钟（44 ± 11 比 50 ± 6，p = 0.002）、第 3 分钟（51 ± 7 比 63 ± 8，p < 0.001）、第 4 分钟（54 ± 7 比 65 ± 8，p < 0.001）和第 5 分钟（57 ± 8 比 70 ± 10，p < 0.001）时的 HRR 指数明显低于健康对照组。此外，HRR1 与银屑病的持续时间呈显著相关（r = 0.541，p < 0.001），与银屑病面积和严重程度指数评分呈显著相关（r = 0.511，p < 0.001）。
结论
银屑病患者的 HRR 较低。鉴于该测试的预后价值，银屑病患者可能存在未来心血管事件和心血管死亡的风险。
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