Karakulak Ugur Nadir, Okutucu Sercan, Şahiner Levent, Maharjan Naresh, Aladag Elifcan, Akdogan Ali, Kilic Levent, Kaya Ergun Baris, Aytemir Kudret, Tokgozoglu Lale
Department of Cardiology, Division of Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Med Princ Pract. 2015;24(1):17-22. doi: 10.1159/000368359. Epub 2014 Nov 22.
To assess exercise heart rate recovery (HRR) indices in patients with systemic sclerosis (SSc) for an assessment of their cardiac autonomic function.
Thirty-five patients with diffuse or limited SSc and 35 healthy controls were enrolled. All subjects underwent exercise testing and transthoracic echocardiography. The HRR indices were calculated by subtracting the first- (HRR1), second- (HRR2) and third-minute (HRR3) heart rates from the maximal heart rate.
The SSc and control groups were similar in age (45.2 ± 11.6 vs. 43.9 ± 10.0 years), had identical gender ratios (31 female/4 male in both groups) and similar left ventricular ejection fraction (66.5 ± 5.1 vs. 67.7 ± 5.9%). The mean HRR1 (21.8 ± 4.4 vs. 27.7 ± 4.3 bpm, p = 0.001), HRR2 (43.8 ± 6.3 vs. 47.6 ± 4.4 bpm, p = 0.004) and HRR3 (58.8 ± 10.3 vs. 63.6 ± 7.3 bpm, p = 0.031) values were significantly lower in the SSc group than in the healthy controls. HRR indices were similar in the limited and diffuse SSc subgroups.
The patients with SSc had lower HRR indices than normal subjects. Cardiac autonomic functions might be involved in SSc, even in patients without cardiac symptoms.
评估系统性硬化症（SSc）患者的运动心率恢复（HRR）指标，以评估其心脏自主神经功能。
纳入35例弥漫性或局限性SSc患者及35名健康对照者。所有受试者均接受运动试验和经胸超声心动图检查。HRR指标通过用最大心率减去第1分钟（HRR1）、第2分钟（HRR2）和第3分钟（HRR3）的心率来计算。
SSc组和对照组年龄相似（45.2±11.6岁 vs. 43.9±10.0岁），性别比例相同（两组均为31名女性/4名男性），左心室射血分数相似（66.5±5.1% vs. 67.7±5.9%）。SSc组的平均HRR1（21.8±4.4 vs. 27.7±4.3次/分钟，p = 0.001）、HRR2（43.8±6.3 vs. 47.6±4.4次/分钟，p = 0.004）和HRR3（58.8±10.3 vs. 63.6±7.3次/分钟，p = 0.031）值显著低于健康对照组。局限性和弥漫性SSc亚组的HRR指标相似。
SSc患者的HRR指标低于正常受试者。即使在没有心脏症状的患者中，心脏自主神经功能可能也参与到了SSc的发病过程中。
