Prado J Valeria, Esparza M Mario, Vidal A Roberto, Durán T Claudia
Programa de Microbiología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Rev Med Chil. 2013 Mar;141(3):291-7. doi: 10.4067/S0034-98872013000300002.
Copper has a bactericidal activity against a series of bacterial strains.
To measure resistance to bacterial adherence of copper (Cu) and stainless steel (SS) metal coupons.
Bacterial strains causing nosocomial infections in Chile were analyzed. Bacterial adherence was studied using a previously described method based on a system of metal coupons that are immersed in culture media containing the bacteria of interest at room temperature.
Adherence to Cu and SS coupons was different for Methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae and Acinetobacter baumannii strains. For these strains, no adherence to Cu coupons occurred during the 48 h observation period compared to a rapidly increasing adherence to SS coupons, with a final colony count of 1.00 E + 07 cfu/mL. For two different Pseudomonas aeruginosa clinical strains, inhibition of adherence was not observed on Cu coupons, and colony counts were similar for Cu and SS using the standard inoculum (2-3 x lO7 cfu).A partial decrease in adherence was observed for Cu but not for SS coupons, when a lower inoculum was used.
Copper surfaces represent an interesting option to reduce bacterial contamination in the hospital environment due to its resistance to bacterial adhesión of most of the common nosocomial bacterial strains.
铜对一系列细菌菌株具有杀菌活性。
测定铜（Cu）和不锈钢（SS）金属试片对细菌黏附的抗性。
对智利医院感染中分离出的细菌菌株进行分析。采用先前描述的方法，基于将金属试片浸入含有目标细菌的培养基中的系统，在室温下研究细菌黏附情况。
耐甲氧西林金黄色葡萄球菌（MRSA）、肺炎克雷伯菌和鲍曼不动杆菌菌株在铜和不锈钢试片上的黏附情况不同。对于这些菌株，在48小时观察期内，未观察到其在铜试片上的黏附，而在不锈钢试片上的黏附迅速增加，最终菌落计数为1.00 E + 07 cfu/mL。对于两种不同的铜绿假单胞菌临床菌株，在铜试片上未观察到黏附抑制，使用标准接种量（2 - 3×10⁷ cfu）时，铜试片和不锈钢试片上的菌落计数相似。当使用较低接种量时，观察到铜试片上的黏附有部分减少，而不锈钢试片上则没有。
由于铜表面对大多数常见医院感染细菌菌株的细菌黏附具有抗性，因此是减少医院环境中细菌污染的一个有吸引力的选择。
