铜及铜合金对西开普省医疗机构分离出的医院病原体和结核分枝杆菌的抗菌活性：一项体外研究。
The antimicrobial activity of copper and copper alloys against nosocomial pathogens and Mycobacterium tuberculosis isolated from healthcare facilities in the Western Cape: an in-vitro study.
作者信息
Mehtar S, Wiid I, Todorov S D
机构信息
Academic Unit for Infection Prevention and Control, Department of Community Health, University of Health Sciences, Faculty of Health Sciences, Tygerberg, Western Cape, South Africa.
出版信息
J Hosp Infect. 2008 Jan;68(1):45-51. doi: 10.1016/j.jhin.2007.10.009. Epub 2007 Dec 11.
Clinical isolates of meticillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Candida albicans and Mycobacterium tuberculosis (MTB) were tested against copper (Cu) and its alloys. Stainless steel and polyvinylchloride (PVC) were used as controls. The amount of Cu required to inhibit test isolates at room temperature (24 degrees C) and at 4 degrees C was determined. At room temperature, Cu, DZR Brass (Cu 62%, Pb 2.5%, arsenate 0.13% and Zn 22.5%) and Brass 70/30 (Cu 70% and zinc 30%) inhibited C. albicans and K. pneumoniae at 60 min; nickel silver (NiAg) inhibited C. albicans at 60 min and K. pneumoniae at 270 min. P. aeruginosa was inhibited by Brass 70/30 and nickel silver (NiAg) at 180 min and at 270 min by Cu and DZR. Cu and DZR inhibited A. baumannii at 180 min while the other alloys were effective at 360 min. Stainless steel and PVC showed little or no inhibitory activity. Two M. tuberculosis strains, one isoniazid resistant (R267) and the other multidrug resistant (R432), demonstrated growth inhibition with Cu of 98% and 88% respectively compared with PVC; the other alloys were less active. Time to positivity (TTP) for R267 was >15 days with Cu and 11 days for the other alloys; with R432 it was 5 days. Effective inhibition of nosocomial pathogens and MTB by Cu and alloys was best when the Cu content was >55%.
对耐甲氧西林金黄色葡萄球菌（MRSA）、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌、白色念珠菌和结核分枝杆菌（MTB）的临床分离株进行了铜（Cu）及其合金的测试。使用不锈钢和聚氯乙烯（PVC）作为对照。测定了在室温（24摄氏度）和4摄氏度下抑制测试分离株所需的铜量。在室温下，铜、含砷黄铜（Cu 62%、Pb 2.5%、砷酸盐0.13%和Zn 22.5%）和70/30黄铜（Cu 70%和锌30%）在60分钟时抑制白色念珠菌和肺炎克雷伯菌；镍银（NiAg）在60分钟时抑制白色念珠菌，在270分钟时抑制肺炎克雷伯菌。70/30黄铜和镍银（NiAg）在180分钟时抑制铜绿假单胞菌，铜和含砷黄铜在270分钟时抑制。铜和含砷黄铜在180分钟时抑制鲍曼不动杆菌，而其他合金在360分钟时有效。不锈钢和PVC显示出很少或没有抑制活性。两株结核分枝杆菌菌株，一株对异烟肼耐药（R267），另一株耐多药（R432），与PVC相比，分别显示出98%和88%的铜生长抑制率；其他合金的活性较低。R267的阳性时间（TTP）用铜时>15天，用其他合金时为11天；R432为5天。当铜含量>55%时，铜及其合金对医院病原体和结核分枝杆菌的有效抑制效果最佳。
Zotero 插件