疟原虫红细胞膜蛋白 1 胞内结构域在疟疾暴露儿童和成人中的血清反应性。
Seroreactivity to Plasmodium falciparum erythrocyte membrane protein 1 intracellular domain in malaria-exposed children and adults.
机构信息
Howard Hughes Medical Institute/Center for Vaccine Development, University of Maryland School of Medicine, Baltimore.
出版信息
J Infect Dis. 2013 Nov 1;208(9):1514-9. doi: 10.1093/infdis/jit339. Epub 2013 Jul 30.
Abstract
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens mediate parasite sequestration and host immune evasion. Reactivity to 21 PfEMP1 fragments on a protein microarray was measured in serum samples from Malian children aged 1-6 years and adults. Seroreactivity to PfEMP1 fragments was higher in adults than in children; intracellular conserved fragments were more widely recognized than were extracellular hypervariable fragments. Over a malaria season, children maintained this differential seroreactivity and recognized additional intracellular PfEMP1 fragments. This approach has the potential to identify conserved, seroreactive extracellular PfEMP1 domains critical for protective immunity to malaria.
摘要
恶性疟原虫红细胞膜蛋白 1（PfEMP1）抗原介导寄生虫的附着和宿主免疫逃逸。在马里 1-6 岁儿童和成年人的血清样本中，通过蛋白微阵列测量了对 21 个 PfEMP1 片段的反应性。成年人对 PfEMP1 片段的血清反应性高于儿童；细胞内保守片段比细胞外高变片段被更广泛地识别。在一个疟疾季节中，儿童保持这种差异的血清反应性，并识别额外的细胞内 PfEMP1 片段。这种方法有可能鉴定出保守的、血清反应性的细胞外 PfEMP1 结构域，这些结构域对疟疾的保护性免疫至关重要。
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