Somani R R, Bhanushali U V
Department of Pharmaceutical Chemistry, VES's College of Pharmacy, Chembur, Mumbai-400 074, India.
Indian J Pharm Sci. 2013 Jan;75(1):3-10. doi: 10.4103/0250-474X.113529.
Recent advances in cancer research highlighted the importance of target-specific drug discovery. In view of these advances, the most important mechanism in tumour growth is its ability to stimulate the formation of blood capillaries around itself called tumour-driven angiogenesis. Hence targeting the angiogenesis, inhibits the growth of blood vessels around it and responsible for death of the tumour due to starvation and accumulation of toxic waste. The therapy, thus, indirectly cytotoxic to the tumour cells by targeting newly developing blood vessels. In this review, we summarised the various antiangiogenic agents with their clinical uses and current status.
癌症研究的最新进展凸显了靶向特异性药物研发的重要性。鉴于这些进展，肿瘤生长中最重要的机制是其刺激自身周围形成毛细血管的能力，即肿瘤驱动的血管生成。因此，针对血管生成进行靶向治疗，可抑制肿瘤周围血管的生长，并导致肿瘤因饥饿和有毒废物积累而死亡。因此，这种疗法通过靶向新生成的血管对肿瘤细胞具有间接的细胞毒性。在本综述中，我们总结了各种抗血管生成药物及其临床应用和现状。
