Gheissari Alaleh, Moghim Sharareh, Navaie Safoora, Merrikhi Alireza, Madihi Yahya
Department of Pediatric Nephrology, Isfahan Kidney Diseases Research Center, Child Growth and Development Research Center, Isfahan, Iran.
J Res Med Sci. 2013 Jan;18(1):61-4.
BK virus (BKV) is ubiquitous in human beings. Virus reactivation may occur in immunocompromised settings. The aim of this study was to compare BKV excretion in acquired immunocompromised children (kidney transplant recipients and steroid resistant nephrotic syndrome) with normal population.
One hundred and thirty one participants less than 20 years were recruited in the case-control study from June 2009 to December 2010. The participants consisted of 40 patients with steroid resistant nephrotic syndrome (subgroup 1), 39 kidney transplant recipients (subgroup 2) and 52 normal populations as control group. The first morning urine samples were analyzed in duplicate by conventional polymerase chain reaction (PCR) method for BKV.
Nine participants out of 131 had positive results for BKV. Three patients in subgroup 1 (7.5%), two patients in subgroup 2 (5.1%) and six people (11.5%) in the control group had positive PCR results for urinary BKV. No significant difference was noted among groups, P = 0.53. The mean of glomerolar filtration rates in participants with positive and negative results for BKV were 125.5 ± 30.8 ml/min/m(2) and 132.2 ± 42.5 ml/min/m(2) respectively, P = 0.8.
Acquired immunocompromised conditions did not increase the chance of urine BKV excretion in our study.
BK病毒（BKV）在人类中普遍存在。病毒再激活可能发生在免疫功能低下的情况下。本研究的目的是比较获得性免疫功能低下儿童（肾移植受者和激素抵抗型肾病综合征患者）与正常人群中BKV的排泄情况。
2009年6月至2010年12月，在病例对照研究中招募了131名20岁以下的参与者。参与者包括40例激素抵抗型肾病综合征患者（亚组1）、39例肾移植受者（亚组2）和52名正常人群作为对照组。采用常规聚合酶链反应（PCR）方法对晨尿样本进行一式两份分析，检测BKV。
131名参与者中有9人BKV检测结果为阳性。亚组1中有3例患者（7.5%）、亚组2中有2例患者（5.1%）以及对照组中有6人（11.5%）尿BKV的PCR检测结果为阳性。各组之间未观察到显著差异，P = 0.53。BKV检测结果为阳性和阴性的参与者的肾小球滤过率平均值分别为125.5±30.8 ml/min/m²和132.2±42.5 ml/min/m²，P = 0.8。
在我们的研究中，获得性免疫功能低下的情况并未增加尿中BKV排泄的几率。
