Elingaramil Sauli, Li Xiaolong, He Nongyue
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, R R. China.
J Nanosci Nanotechnol. 2013 Jul;13(7):4539-51. doi: 10.1166/jnn.2013.7522.
Next-generation sequencing technologies, microarrays and advances in bio nanotechnology have had an enormous impact on research within a short time frame. This impact appears certain to increase further as many biomedical institutions are now acquiring these prevailing new technologies. Beyond conventional sampling of genome content, wide-ranging applications are rapidly evolving for next-generation sequencing, microarrays and nanotechnology. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted re sequencing and discovery of transcription factor binding sites, noncoding RNA expression profiling and molecular diagnostics. This paper thus discusses current applications of nanotechnology, next-generation sequencing technologies and microarrays in biomedical research and highlights the transforming potential these technologies offer.
新一代测序技术、微阵列技术以及生物纳米技术的进展在短时间内对研究产生了巨大影响。随着许多生物医学机构目前正在购置这些流行的新技术，这种影响似乎肯定会进一步增强。除了对基因组内容进行常规采样外，新一代测序、微阵列和纳米技术的广泛应用正在迅速发展。迄今为止，这些技术已应用于多种情形，包括全基因组测序、靶向重测序以及转录因子结合位点的发现、非编码RNA表达谱分析和分子诊断。因此，本文讨论了纳米技术、新一代测序技术和微阵列技术在生物医学研究中的当前应用，并强调了这些技术所具有的变革潜力。
