School of Engineering and the Institute of Nanotechnology & Advanced Materials, Bar Ilan University, Ramat Gan, 52900, Israel.
Nanomedicine (Lond). 2012 Feb;7(2):257-69. doi: 10.2217/nnm.11.190.
The importance of computed tomography (CT) as one of the leading radiology technologies applied in the field of biomedical imaging escalated the development of nanoparticles as the next generation CT contrast agents. Nanoparticles are expected to play a major role in the future of medical diagnostics due to their many advantages over the conventional contrast agents, such as prolonged blood circulation time, controlled biological clearance pathways and specific molecular targeting capabilities. This paper will describe the basic design principles of nanoparticle-based CT contrast agents and review the state-of-the-art developments and clinical applications of blood pool, passive and active targeting CT contrast agents.
计算机断层扫描（CT）作为生物医学成像领域应用的主要放射学技术之一，其重要性日益提升，推动了纳米颗粒作为下一代 CT 对比剂的发展。纳米颗粒由于具有比传统对比剂更多的优势，例如延长血液循环时间、控制生物清除途径和特定的分子靶向能力，有望在未来的医学诊断中发挥重要作用。本文将描述基于纳米颗粒的 CT 对比剂的基本设计原则，并综述血池、被动和主动靶向 CT 对比剂的最新发展和临床应用。
