Chakor Rahul Tryambak, Santosh Nandanavana Subbareddy
Department of Neurology, Topiwala National Medical College, BYL Nair Charitable Hospital, Mumbai Central, Mumbai, India.
J Pak Med Assoc. 2013 Jul;63(7):921-4.
Onset of dementia before 65 years of age is termed as young-onset dementia (YOD). Very little literature exists regarding the clinical features and diagnoses of dementia in younger individuals. We present a case series of four patients of age 10 to 23 years with severe dementia within 18 months of clinical onset (rapidly progressive dementia). Three patients had generalised periodic complexes typical of subacute sclerosing panencephalitis (SSPE) on electroencephalogram (EEG). All patients had elevated cerebrospinal fluid (CSF) IgG measles antibodies. Our case series highlights that SSPE is an important cause of rapidly progressive YOD in developing countries like India.
65岁之前出现的痴呆被称为早发性痴呆（YOD）。关于年轻个体痴呆的临床特征和诊断的文献非常少。我们报告了一组病例，4名年龄在10至23岁之间的患者在临床发病后18个月内出现严重痴呆（快速进展性痴呆）。3名患者脑电图（EEG）显示有亚急性硬化性全脑炎（SSPE）典型的全身性周期性复合波。所有患者脑脊液（CSF）中麻疹IgG抗体均升高。我们的病例系列突出表明，在印度等发展中国家，SSPE是快速进展性早发性痴呆的一个重要原因。
