Fulton J E, Arango J, Arthur J A, Settar P, Kreager K S, O'Sullivan N P
Hy-Line International, P.O. Box 310, Dallas Center, 1A 50063, USA.
Avian Dis. 2013 Jun;57(2 Suppl):519-22. doi: 10.1637/10408-100212-Reg.1.
A challenge test following inoculation with a standard amount of a vv+ strain of the Marek's disease (MD) virus in multiple lines and multiple generations of egg type chicken and the corresponding phenotypic trend are described. This program significantly reduced mortality of progeny from selected sires for three to 11 generations in eight of the nine elite lines studied herein. In brown egg lines, a retrospective analysis of DNA indicated an association between the blood type B (major histocompatibility complex) of the sire and the MD mortality in the challenge of its progeny. As a result of the multigeneration stock amplification and crossbreeding processes used in the commercial breeding industry, improvement in survival after challenge at the elite level will translate to improved welfare for millions of birds at the commercial production level.
本文描述了在多品系、多代蛋鸡中接种标准量的马立克氏病（MD）vv+毒株后的攻毒试验以及相应的表型趋势。该方案显著降低了本文研究的九个精英品系中八个品系选定父系后代三至十一代的死亡率。在褐壳蛋鸡品系中，对DNA的回顾性分析表明，父系的B血型（主要组织相容性复合体）与其后代攻毒试验中的MD死亡率之间存在关联。由于商业育种行业采用了多代扩群和杂交过程，精英水平上攻毒后存活率的提高将转化为商业生产水平上数百万只鸡福利的改善。
