Graduate School of Science, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.
Org Lett. 2013 Aug 16;15(16):4194-7. doi: 10.1021/ol401906q. Epub 2013 Jul 31.
A variety of methylarenes were successfully converted into the corresponding aromatic nitriles in good to moderate yields by the treatment with NBS or DBDMH in the presence of a catalytic amount of AIBN or BPO, followed by the reaction with molecular iodine in aq NH3 in a one-pot procedure. The present reaction is a useful and practical transition-metal-free method for the preparation of aromatic nitriles from methylarenes.
通过在催化量的 AIBN 或 BPO 存在下用 NBS 或 DBDMH 处理，然后在 aq NH3 中与分子碘一锅反应，成功地将各种甲基芳烃转化为相应的芳香腈，产率为好到中等。该反应是一种有用且实用的无过渡金属方法，可从甲基芳烃制备芳香腈。
