原子经济性、一锅法、三反应级联反应构建新型三环 2,4-二氢-1H-苯并[f]异喹啉。
Atom economical, one-pot, three-reaction cascade to novel tricyclic 2,4-dihydro-1H-benzo[f]isochromenes.
机构信息
Department of Chemistry, The College of William & Mary, P.O. Box 8795, Williamsburg, Virginia 23187-8795, USA.
出版信息
Org Lett. 2013 Aug 16;15(16):4070-3. doi: 10.1021/ol401600j. Epub 2013 Aug 1.
Abstract
Reaction of 6-methyl-1-phenylhept-3-yne-2,6-diol with various aldehydes under Lewis acid conditions provides an atom economical, two-component cascade reaction sequence to novel 2,4-dihydro-1H-benzo[f]isochromene compounds. Aliphatic aldehydes as well as electron-deficient and -rich aromatic aldehydes can be used.
摘要
在路易斯酸条件下，6-甲基-1-苯基-3-庚炔-2,6-二醇与各种醛反应，提供了一种原子经济性的、二组分级联反应序列，用于合成新型 2,4-二氢-1H-苯并[f]异色烯化合物。脂肪醛以及缺电子和富电子的芳香醛都可以使用。
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