百日咳博德特氏菌蛋白质组与人猝死蛋白之间的肽段共享：因果关联的假设。
Peptide sharing between Bordetella pertussis proteome and human sudden death proteins: a hypothesis for a causal link.
机构信息
Department of Biosciences, Biotechnologies & Biopharmaceutics, University of Bari, Bari, Italy.
出版信息
Future Microbiol. 2013 Aug;8(8):1039-48. doi: 10.2217/fmb.13.72.
AIM
To explore the molecular basis of the relationship between Bordetella pertussis infection and sudden death.
METHODS
B. pertussis proteins were analyzed for amino acid sequence identity to a set of 67 human proteins that, when altered, have been associated with sudden death.
RESULTS
More than 82,000 pentapeptides are shared between B. pertussis proteins and sudden death-associated antigens.
CONCLUSION
Results suggest that a possible link between B. pertussis infection and sudden death might be represented by potential immunological cross-reactions occurring between B. pertussis proteins and human proteins associated to sudden death.
目的
探索百日咳博德特氏菌感染与猝死之间关系的分子基础。
方法
分析百日咳博德特氏菌蛋白与一组 67 个人类蛋白的氨基酸序列同一性，这些人类蛋白发生改变时与猝死有关。
结果
在百日咳博德特氏菌蛋白和猝死相关抗原之间有超过 82000 个五肽共享。
结论
结果表明，百日咳博德特氏菌感染和猝死之间可能存在联系，这可能是由百日咳博德特氏菌蛋白与与猝死相关的人类蛋白之间发生潜在的免疫交叉反应所代表。
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