Bergeret A, Pouget E, Tedone R, Meygret T, Cadot R, Descotes J
Institut Universitaire de Médecine du Travail, Lyon, France.
Hum Exp Toxicol. 1990 Jul;9(4):231-3. doi: 10.1177/096032719000900405.
Neutrophil functions were studied in 38 lead-exposed workers compared to 34 controls. Both groups were matched according to age, sex, drinking and smoking habits, ethnic origin and drug intake. Blood lead levels were found to be seven times higher in exposed workers than in controls. Phagocytosis assayed by chemiluminescence was found to be slightly but not significantly altered in exposed workers. In contrast, chemotaxis using the agarose technique was significantly depressed. These results are in agreement with previous in-vitro findings. A further assessment of clinical consequences is warranted.
对38名铅暴露工人的中性粒细胞功能进行了研究，并与34名对照组进行了比较。两组根据年龄、性别、饮酒和吸烟习惯、种族和药物摄入情况进行匹配。发现暴露工人的血铅水平比对照组高7倍。通过化学发光测定的吞噬作用在暴露工人中略有改变，但无显著差异。相比之下，使用琼脂糖技术的趋化性则显著降低。这些结果与之前的体外研究结果一致。有必要进一步评估其临床后果。
