Queiroz M L, Almeida M, Gallão M I, Höehr N F
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, SP, Brazil.
Pharmacol Toxicol. 1993 Feb;72(2):73-7. doi: 10.1111/j.1600-0773.1993.tb00293.x.
Chemotaxis and nitroblue tetrazolium reduction were measured in peripheral blood neutrophils of workers occupationally exposed to lead. These two neutrophil functions were significantly reduced, as compared to controls, even in those workers with blood lead levels and urinary delta-aminolevulinic acid (ALA-U) concentrations below the currently accepted biological limit values of 60 micrograms/dl and 6 mg/l, respectively. The immunosuppressive effects of relatively low level lead absorption suggests that immune dysfunction may be a sensitive indicator of lead exposure.
对职业性接触铅的工人外周血中性粒细胞进行趋化性和硝基蓝四氮唑还原试验检测。与对照组相比，即使是那些血铅水平和尿δ-氨基乙酰丙酸（ALA-U）浓度分别低于目前公认的生物限值60微克/分升和6毫克/升的工人，这两种中性粒细胞功能也显著降低。相对低水平铅吸收的免疫抑制作用表明，免疫功能障碍可能是铅暴露的一个敏感指标。
