Chu H, Yan F, Zhao J, Xu Y, Wang T, Li K, Tang J, Guo W
Center of General Surgery, The 89th Hospital of People's Liberation Army, Weifang, China.
Int Angiol. 2013 Oct;32(5):459-64.
The purpose of this study was to investigate the proliferation of vasa vasorum (VV) in the walls of thrombophlebitic saphenous vein (TSV), and to evaluate the influence of high venous pressure and lack of oxygen on the VV.
The specimens of the great saphenous vein were collected: 11 primary varicose vein (PVV), 11 TSV and, as a control, eight normal great saphenous vein. Masson staining and immunohistochemistry for CD34 were used to observe the status of VV, and the number of VV were counted under light microscopy.
VV of the thrombophlebitic saphenous vein group (TSVG) were clustered together in adventitia, increased linearly in media, and scattered appearance in intima, were increased partially in intima of thrombus rupturing. In TSVG, the number of VV observed in adventitia, media and intima was 16.738±7.685, 4.845±2.537, 2.448±3.030, respectively. In the primary varicose vein group (PVVG), the corresponding values were 14.280±4.440, 2.965±1.125, 0.500±0.548. And the number was 8.911±2.629, 0.150±0.424, 0±0 in the control group (CG). Significantly higher numbers of VV were observed in the TSVG as compared to the PVVG or CG (P<0.05). No significant difference was observed between intima and media (P>0.05).
Thrombi in varicose veins can induce proliferation of VV, which may be involved in high venous pressure and hypoxia.
本研究旨在探讨血栓性隐静脉（TSV）壁中血管滋养血管（VV）的增殖情况，并评估高静脉压和缺氧对VV的影响。
收集大隐静脉标本：11例原发性静脉曲张（PVV）、11例TSV，以及作为对照的8例正常大隐静脉。采用Masson染色和CD34免疫组化观察VV的状态，并在光学显微镜下计数VV的数量。
血栓性隐静脉组（TSVG）的VV在外膜聚集，在中膜呈线性增加，在内膜呈散在分布，在血栓破裂的内膜部分增加。在TSVG中，外膜、中膜和内膜观察到的VV数量分别为16.738±7.685、4.845±2.537、2.448±3.030。在原发性静脉曲张组（PVVG）中，相应的值分别为14.280±4.440、2.965±1.125、0.500±0.548。而在对照组（CG）中，数量分别为8.911±2.629、0.150±0.424、0±0。与PVVG或CG相比，TSVG中观察到的VV数量显著更高（P<0.05）。内膜和中膜之间未观察到显著差异（P>0.05）。
静脉曲张中的血栓可诱导VV增殖，这可能与高静脉压和缺氧有关。
