[Gd(CyPic3A)(H2O)2]-：一种稳定的、双（水合）和高弛豫率的 Gd(III) 配合物。
[Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complex.
机构信息
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
出版信息
Chem Commun (Camb). 2013 Sep 21;49(73):8060-2. doi: 10.1039/c3cc44116d. Epub 2013 Aug 1.
Abstract
We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. Gd(CyPic3A)(H2O)2 affords an r1 value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.
摘要
我们报告了 CyPic3A 的合成及其与磁共振相关的性质，CyPic3A 是一种七齿配体，可形成水合状态 q = 2 的三元 Gd(III)配合物。Gd(CyPic3A)(H2O)2在 1.41 T 和 310 K 时的 r1 值为 5.70 mM(-1) s(-1)，显示出与 FDA 批准的磁共振成像探针相当的热力学稳定性和动力学惰性。
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