Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus, Wood Lane, London, W12 0BZ, UK.
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China.
Nat Commun. 2019 Mar 29;10(1):1420. doi: 10.1038/s41467-019-09342-3.
Gadolinium(III) complexes have been widely utilised as magnetic resonance imaging (MRI) contrast agents for decades. In recent years however, concerns have developed about their toxicity, believed to derive from demetallation of the complexes in vivo, and the relatively large quantities of compound required for a successful scan. Recent efforts have sought to enhance the relaxivity of trivalent gadolinium complexes without sacrificing their stability. This review aims to examine the strategic design of ligands synthesised for this purpose, provide an overview of recent successes in gadolinium-based contrast agent development and assess the requirements for clinical translation.
钆（III）配合物作为磁共振成像（MRI）对比剂已被广泛应用数十年。然而，近年来人们对其毒性产生了担忧，据信这种毒性源于体内配合物的脱金属作用，以及为成功进行扫描所需的相对大量的化合物。最近的研究旨在提高三价钆配合物的弛豫率，同时不牺牲其稳定性。本综述旨在检查为此目的合成的配体的战略设计，概述最近在基于钆的对比剂开发方面的成功，并评估其临床转化的要求。
