Department of Chemistry-Université de Montréal, 2900 Edouard Montpetit, CP 6128 Succursalle Centre ville, Montréal, QC, Canada H3C3J7.
Org Biomol Chem. 2013 Sep 28;11(36):6023-8. doi: 10.1039/c3ob41209a.
We report the synthesis and assembly of umbrella-rotaxanes with transmembrane transport properties. We describe their amphomorphism and validate their ability to penetrate and cross phospholipid bilayers. Furthermore we present the strategy to release the macrocyclic compound by enzymatic cleavage inside egg yolk phosphatidylcholine (EYPC) liposomes.
我们报告了具有跨膜转运性质的伞状轮烷的合成和组装。我们描述了它们的两亲性，并验证了它们穿透和穿过磷脂双层的能力。此外，我们还提出了通过在蛋黄卵磷脂（EYPC）脂质体中酶促裂解来释放大环化合物的策略。
