Bipolar Disorder Program (PROTAHBI) and National Science and Technology Institute for Translational Medicine (INCT-TM), Hospital de ClÍnicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Braz J Psychiatry. 2013 Apr-Jun;35(2):126-30. doi: 10.1590/1516-4446-2011-0768.
Bipolar disorder (BD) is associated with significant morbidity and mortality due to comorbid general medical conditions, particularly cardiovascular disease. This study is the first report of the Brazilian Research Network in Bipolar Disorder (BRN-BD) that aims to evaluate the prevalence and clinical correlates of cardiovascular risk factors among Brazilian patients with BD.
A cross-sectional study of 159 patients with DSM-IV BD, 18 years or older, consecutively recruited from the Bipolar Research Program (PROMAN) in São Paulo and the Bipolar Disorder Program (PROTAHBI) in Porto Alegre. Clinical, demographic, anthropometric, and metabolic variables were systematically assessed.
High rates of smoking (27%), physical inactivity (64.9%), alcohol use disorders (20.8%), elevated fasting glucose (26.4%), diabetes (13.2%), hypertension (38.4%), hypertriglyceridemia (25.8%), low HDL-cholesterol (27.7%), general (38.4%) and abdominal obesity (59.1%) were found in the sample. Male patients were more likely to have alcohol use disorders, diabetes, and hypertriglyceridemia, whereas female patients showed higher prevalence of abdominal obesity. Variables such as medication use pattern, alcohol use disorder, and physical activity were associated with selected cardiovascular risk factors in the multivariable analysis.
This report of the BRN-BD provides new data regarding prevalence rates and associated cardiovascular risk factors in Brazilian outpatients with BD. There is a need for increasing both awareness and recognition about metabolic and cardiovascular diseases in this patient population.
双相情感障碍（BD）与合并的一般医学状况相关，尤其是心血管疾病，导致发病率和死亡率显著增加。本研究是巴西双相情感障碍研究网络（BRN-BD）的首次报告，旨在评估巴西 BD 患者心血管危险因素的患病率和临床相关性。
这是一项横断面研究，共纳入 159 例 18 岁及以上的 DSM-IV 双相情感障碍患者，他们均来自圣保罗的双相情感障碍研究计划（PROMAN）和阿雷格里港的双相情感障碍计划（PROTAHBI）。系统评估了临床、人口统计学、人体测量和代谢变量。
该样本中存在高比例的吸烟（27%）、身体活动不足（64.9%）、酒精使用障碍（20.8%）、空腹血糖升高（26.4%）、糖尿病（13.2%）、高血压（38.4%）、高三酰甘油血症（25.8%）、低高密度脂蛋白胆固醇（27.7%）、全身性肥胖（38.4%）和腹型肥胖（59.1%）。男性患者更可能患有酒精使用障碍、糖尿病和高三酰甘油血症，而女性患者则表现出更高的腹型肥胖患病率。在多变量分析中，药物使用模式、酒精使用障碍和身体活动等变量与某些心血管危险因素相关。
BRN-BD 的这份报告提供了巴西门诊 BD 患者患病率和相关心血管危险因素的新数据。需要提高该患者群体对代谢和心血管疾病的认识和识别。
