锂盐治疗期间双相情感障碍患者左心室收缩和舒张功能的评估。

Evaluation of left ventricular systolic and diastolic functions in bipolar patients during lithium therapy.

作者信息

Zencir Cemil, Ozdemiroglu Filiz A, Cetin Mustafa, Avcil Sibel N, Selvi Mithat, Gungor Hasan, Akgullu Cagdas, Findikli Ebru, Acar Gurkan

机构信息

Department of Cardiology, School of Medicine, Adnan Menderes University Turkey.

Department of Psychiatry, School of Medicine, Adnan Menderes University Turkey.

出版信息

Int J Clin Exp Med. 2015 Feb 15;8(2):2917-22. eCollection 2015.

PMID:25932255

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4402902/

Abstract

BACKGROUND

Bipolar disorder (BD) is a chronic mental illness that is associated with substantial functional impairment, morbidity and mortality. Lithium is still considered as a first-line therapy in BD. In this study, systolic and diastolic function parameters were measured with echocardiography in BD during lithium therapy and compared to those of a control group.

METHODS

Thirty BD under lithium therapy and controls were included in our study. Blood samples were taken 12 hours after receiving the last dose of lithium treatment, in the meantime echocardiography were performed. Left ventricular systolic and diastolic function was assessed by conventional echocardiography and tissue Doppler imaging. Serum lithium level correlation between diastolic function parameters was measured.

RESULTS

Baseline demographic and laboratory results did not differ significantly between the groups. Left ventricular ejection fraction (LVEF) (66.7 ± 7.1% vs 66.7 ± 4.9%), E/A ratio (1.14 ± 0.41 vs 1.28 ± 0.29), and isovolumetric relaxation time (IVRT) (77.8 ± 14.5 cm/sec vs 75.9 ± 17.7cm/sec) measured with conventional echocardiography showed no significant difference between the two groups. Em (14.8 ± 5.2 cm/sec vs 15 ± 4.6 cm/sec), Am (12.7 ± 4.0 cm/sec vs 11.1.0 ± 2.4 cm/sec) and E/Em (5.5 ± 1.8 vs 5.9 ± 2.4) measured with tissue Doppler echocardiography showed no significant difference between the two groups. Serum lithium levels were not correlated with LVEF, mitral inflow E velocity, mitral inflow A velocity, E/A ratio, deceleration time (DT), IVRT, or E/Em ratio.

CONCLUSION

Left ventricular systolic and diastolic functions were preserved in BD during lithium therapy.

摘要

背景

双相情感障碍（BD）是一种慢性精神疾病，与严重的功能损害、发病率和死亡率相关。锂盐仍然被认为是双相情感障碍的一线治疗药物。在本研究中，通过超声心动图测量双相情感障碍患者在锂盐治疗期间的收缩和舒张功能参数，并与对照组进行比较。

方法

本研究纳入了30例接受锂盐治疗的双相情感障碍患者和对照组。在接受最后一剂锂盐治疗12小时后采集血样，同时进行超声心动图检查。通过传统超声心动图和组织多普勒成像评估左心室收缩和舒张功能。测量血清锂水平与舒张功能参数之间的相关性。

结果

两组之间的基线人口统计学和实验室结果无显著差异。用传统超声心动图测量的左心室射血分数（LVEF）（66.7±7.1%对66.7±4.9%）、E/A比值（1.14±0.41对1.28±0.29）和等容舒张时间（IVRT）（77.8±14.5 cm/秒对75.9±17.7 cm/秒）在两组之间无显著差异。用组织多普勒超声心动图测量的Em（14.8±5.2 cm/秒对15±4.6 cm/秒）、Am（12.7±4.0 cm/秒对11.1.0±2.4 cm/秒）和E/Em（5.5±1.8对5.9±2.4）在两组之间无显著差异。血清锂水平与LVEF、二尖瓣流入E速度、二尖瓣流入A速度、E/A比值、减速时间（DT）、IVRT或E/Em比值无关。