RAND Corporation, 1776 Main St., Santa Monica, CA, 90407, USA,
AIDS Behav. 2013 Nov;17(9):3059-65. doi: 10.1007/s10461-013-0550-9.
To pilot the adherence readiness program, 60 patients planning to start HIV antiretrovirals were assigned to usual care (n = 31) or the intervention (n = 29), of whom 54 started antiretrovirals and were followed for up to 24 weeks. At week 24, the intervention had a large effect (50.0 % vs. 16.7 %, d = 0.75) on optimal dose-timing (85+ % doses taken on time) and small effect (54.2 % vs. 43.3 %, d = 0.22) on optimal dose-taking (85+ % doses taken) electronically monitored adherence, and medium effect on undetectable viral load (62 % 0.5 % vs. 43.4 %, d = 0.41), compared to usual care. These intervention benefits on adherence and viral suppression warrant further investigation.
为了试行依从性准备计划，将 60 名计划开始接受 HIV 抗逆转录病毒治疗的患者分配至常规护理组（n = 31）或干预组（n = 29），其中 54 名开始接受抗逆转录病毒治疗，并随访了最多 24 周。在第 24 周时，与常规护理相比，干预措施对最佳剂量时间（85+%的剂量按时服用，d = 0.75）和最佳剂量服用（85+%的剂量服用，d = 0.22）的电子监测依从性有较大影响（50.0% vs. 16.7%），对不可检测的病毒载量有中等影响（62% vs. 43.4%，d = 0.41）。与常规护理相比，这些干预措施在依从性和病毒抑制方面的益处值得进一步研究。
