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Evaluating adherence to highly active antiretroviral therapy with use of pill counts and viral load measurement in the drug resources enhancement against AIDS and malnutrition program in Mozambique.在莫桑比克“增强药物资源防治艾滋病和营养不良项目”中，运用药丸计数法和病毒载量测量法评估高效抗逆转录病毒疗法的依从性。
Clin Infect Dis. 2008 May 15;46(10):1609-16. doi: 10.1086/587659.
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Optimal recall period and response task for self-reported HIV medication adherence.自我报告的HIV药物依从性的最佳回忆期和应答任务。
AIDS Behav. 2008 Jan;12(1):86-94. doi: 10.1007/s10461-007-9261-4. Epub 2007 Jun 19.
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Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomes.坚持基于非核苷类逆转录酶抑制剂的艾滋病治疗及病毒学结果。
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Less than 95% adherence to nonnucleoside reverse-transcriptase inhibitor therapy can lead to viral suppression.对非核苷类逆转录酶抑制剂疗法的依从性低于95%可能导致病毒抑制。
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Repeated measures analyses of dose timing of antiretroviral medication and its relationship to HIV virologic outcomes.抗逆转录病毒药物剂量给药时间的重复测量分析及其与HIV病毒学结果的关系。
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Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness.病毒适应性解释的蛋白酶和非核苷类逆转录酶抑制剂的依从性-耐药性关系。
AIDS. 2006 Jan 9;20(2):223-31. doi: 10.1097/01.aids.0000199825.34241.49.
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Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data.诊断试验数据的汇总受试者工作特征（SROC）曲线的特性。
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剂量时机对于实现病毒载量不可检测的重要性。

Importance of dose timing to achieving undetectable viral loads.

机构信息

Center for International Health and Development, Boston University of Public Health, Boston, MA 02118, USA.

出版信息

AIDS Behav. 2010 Aug;14(4):785-93. doi: 10.1007/s10461-009-9555-9. Epub 2009 Apr 8.

DOI:10.1007/s10461-009-9555-9
PMID:19353263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3857692/
Abstract

Little is known about the importance of dose timing to successful antiretroviral therapy (ART). In a cohort comprised of Chinese HIV/AIDS patients, we measured adherence among subjects for 6 months using three methods in parallel: self-report using a visual analog scale (SR-VAS), pill count, and electronic drug monitors (EDM). We calculated two adherence metrics using the EDM data. The first metric used the proportion of doses taken; the second metric credited doses as adherent only if taken within a 1-h window of a pre-specified dose time (EDM 'proportion taken within dose time'). Of the adherence measures, EDM had the strongest associations with viral suppression. Of the two EDM metrics, incorporating dose timing had a stronger association with viral suppression. We conclude that dose timing is also an important determinant of successful ART, and should be considered as an additional dimension to overall adherence.

摘要

关于剂量时间安排对成功抗逆转录病毒疗法（ART）的重要性知之甚少。在一个由中国 HIV/AIDS 患者组成的队列中，我们使用三种方法并行测量了 6 个月的受试者依从性：使用视觉模拟量表（SR-VAS）的自我报告、药物计数和电子药物监测器（EDM）。我们使用 EDM 数据计算了两个依从性指标。第一个指标使用了服用剂量的比例；第二个指标仅将在规定剂量时间的 1 小时窗口内服用的剂量计为依从性（EDM“剂量时间内服用的比例”）。在这些依从性测量指标中，EDM 与病毒抑制的关联最强。在这两个 EDM 指标中，纳入剂量时间安排与病毒抑制的关联更强。我们得出结论，剂量时间安排也是成功 ART 的一个重要决定因素，应该被视为整体依从性的一个额外维度。