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一名接受免疫抑制治疗的膜性肾小球肾炎患者发生扁桃体卡波西肉瘤。

Tonsillar Kaposi sarcoma in a patient with membranous glomerulonephritis on immunosuppressive therapy.

作者信息

Al-Brahim Nabeel, Zaki Ashraf H, El-Merhi Khaled, Ahmad Mahmoud S

机构信息

Department of Pathology, Farwaniya Hospital, Salmiya, Kuwait 22034.

出版信息

Ear Nose Throat J. 2013 Jul;92(7):E1-4. doi: 10.1177/014556131309200712.

Abstract

Kaposi sarcoma is a malignant vascular neoplasm uncommonly seen in immunosuppressed patients. Herein we report an unusual case of tonsillar Kaposi sarcoma in a patient with membranous glomerulonephritis treated with prednisolone and cyclosporine. The patient presented after 10 months of starting the treatment with a tonsillar mass. Histological examination was typical of monomorphic spindle cell proliferation with slit-like vascular channels. The tumor cells expressed CD34, D2-40 and positive nuclear stain for HHV-8. Kaposi sarcoma is associated with immunosuppression and rarely occurs in the tonsil. Clinicians should be aware of this rare presentation of Kaposi sarcoma.

摘要

卡波西肉瘤是一种恶性血管肿瘤,在免疫抑制患者中不常见。在此,我们报告一例罕见的扁桃体卡波西肉瘤病例,患者为一名患有膜性肾小球肾炎的患者,正在接受泼尼松龙和环孢素治疗。该患者在开始治疗10个月后出现扁桃体肿物。组织学检查显示为典型的单形性梭形细胞增殖,伴有裂隙样血管腔隙。肿瘤细胞表达CD34、D2-40,并且HHV-8核染色呈阳性。卡波西肉瘤与免疫抑制相关,很少发生于扁桃体。临床医生应了解卡波西肉瘤的这种罕见表现。

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