己酸17α羟孕酮（17OHPC）在预防早产中的作用。
Role of 17 α Hydroxy Progesterone Caproate (17OHPC) in the Prevention of Preterm Labor.
作者信息
Nigar Asma, Hakim S, Mohsin Zehra
机构信息
Department of Obstetrics & Gynecology, J N Medical College Aligarh, 4/1049G Medical Road, Dodhpur, Aligarh, 202002 India.
出版信息
J Obstet Gynaecol India. 2012 Aug;62(4):398-400. doi: 10.1007/s13224-012-0290-1. Epub 2012 Oct 23.
OBJECTIVE
To evaluate the role of 17 α hydroxyprogesterone caproate (17OHPC) in the prevention of preterm labor in high risk asymptomatic patients with a history of preterm delivery.
METHODS
The study included 96 patients with a singleton pregnancy and having a prior preterm birth. They were divided in 2 groups, group I (treatment group) included 46 asymptomatic patients who were given 17OHPC injections starting from 16-20 weeks till 36 weeks and group II (control group) included 50 patients who did not receive any treatment.
RESULTS
The incidence of preterm delivery was found to be 6.9 %. The median gestational age at delivery was 36 weeks in group I and 33 W5D in controls. 50 % cases in group I and 80 % of controls delivered prematurely in the group with a prior preterm birth between 20-28 weeks.
CONCLUSION
In patients who had a prior history of a preterm delivery the recurrence of a preterm birth was less in the treated group as compared to controls. The median gestational age at delivery was significantly higher in 17OHPC treated patients with history of earliest prior preterm delivery at 20-28 weeks.
目的
评估己酸17α羟孕酮（17OHPC）在预防有早产史的高危无症状患者早产中的作用。
方法
该研究纳入了96名单胎妊娠且有早产史的患者。他们被分为两组，第一组（治疗组）包括46名无症状患者，从孕16 - 20周开始至36周接受17OHPC注射；第二组（对照组）包括50名未接受任何治疗的患者。
结果
发现早产发生率为6.9%。第一组的中位分娩孕周为36周，对照组为33周5天。在有20 - 28周早产史的组中，第一组50%的病例和对照组80%的病例早产。
结论
与对照组相比，有早产史的患者中，治疗组早产复发率更低。在最早有20 - 28周早产史的患者中，接受17OHPC治疗的患者中位分娩孕周显著更高。
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