Kristensen J, Langhoff-Roos J, Kristensen F B
Department of Obstetrics and Gynecology, Rigshospitalet, University of Copenhagen, Denmark.
Obstet Gynecol. 1995 Nov;86(5):800-4. doi: 10.1016/0029-7844(95)00275-V.
To describe the relationship between pregnancy complications and fetal outcome in first and second pregnancies, focusing on idiopathic and indicated preterm birth of singleton infants in either pregnancy.
Included in the study were 13,967 women in Denmark who gave birth to their first singleton infant in 1982 and a second infant in 1982-1987. Information on pregnancy and birth was obtained by linking the National Medical Birth Register and the National Register of Hospital Discharges, based on personal identification numbers.
The risk of a preterm second birth in women with idiopathic and indicated preterm first birth did not differ significantly (15.2 and 12.8%, respectively). However, women with idiopathic preterm birth in the first pregnancy tended to repeat idiopathic preterm birth twice as often as women with indicated preterm birth repeated indicated preterm birth (11.3 versus 6.4%). Adjustment by logistic regression analysis for other risk factors for preterm birth did not influence the relative risk (6.0 before 32 weeks and 4.8 for 32-36 weeks) of a second preterm birth after a first preterm birth. Women with idiopathic preterm delivery in their first and second pregnancies gave birth to infants with lower birth weight than in previous or subsequent pregnancies. Emergency cesarean delivery in a first term pregnancy was a risk factor for subsequent idiopathic preterm birth.
Idiopathic preterm birth is associated with emergency cesarean delivery at term in previous pregnancies and infants with lower birth weight in previous and subsequent pregnancies.
描述首次和第二次妊娠中妊娠并发症与胎儿结局之间的关系，重点关注单胎妊娠中特发性和指征性早产情况。
纳入研究的是丹麦13967名女性，她们于1982年生育了第一个单胎婴儿，并于1982 - 1987年生育了第二个婴儿。基于个人身份识别号码，通过链接国家医疗出生登记册和国家医院出院登记册获取妊娠和分娩信息。
特发性早产和指征性早产的首次妊娠女性再次早产的风险无显著差异（分别为15.2%和12.8%）。然而，首次妊娠为特发性早产的女性再次发生特发性早产的频率往往是首次妊娠为指征性早产女性再次发生指征性早产频率的两倍（11.3%对6.4%）。对其他早产风险因素进行逻辑回归分析调整后，并未影响首次早产之后第二次早产的相对风险（32周前为6.0，32 - 36周为4.8）。首次和第二次妊娠均为特发性早产的女性所生婴儿的出生体重低于前次或后续妊娠。首次足月妊娠时进行急诊剖宫产是后续特发性早产的一个风险因素。
特发性早产与前次妊娠足月时急诊剖宫产以及前次和后续妊娠中出生体重较低的婴儿有关。
