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1
Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer.肿瘤 STAT3 酪氨酸磷酸化状态作为预测乳腺癌辅助化疗获益的指标。
Breast Cancer Res Treat. 2013 Apr;138(2):407-13. doi: 10.1007/s10549-013-2453-x. Epub 2013 Feb 28.
2
Patient-derived breast tumor xenografts facilitating personalized cancer therapy.患者来源的乳腺肿瘤异种移植有助于个性化癌症治疗。
Breast Cancer Res. 2013 Jan 22;15(1):201. doi: 10.1186/bcr3355.
3
Distinct transcriptional regulatory modules underlie STAT3's cell type-independent and cell type-specific functions.STAT3 的细胞类型非依赖性和细胞类型特异性功能由不同的转录调控模块所支撑。
Nucleic Acids Res. 2013 Feb 1;41(4):2155-70. doi: 10.1093/nar/gks1300. Epub 2013 Jan 7.
4
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.TCPTP 调节 SFK 和 STAT3 信号转导，并且在三阴性乳腺癌中丢失。
Mol Cell Biol. 2013 Feb;33(3):557-70. doi: 10.1128/MCB.01016-12. Epub 2012 Nov 19.
5
Modulation of leptin resistance by protein tyrosine phosphatases.蛋白酪氨酸磷酸酶对瘦素抵抗的调节作用。
Cell Metab. 2012 Mar 7;15(3):292-7. doi: 10.1016/j.cmet.2012.02.004.
6
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.T 细胞急性淋巴细胞白血病中蛋白酪氨酸磷酸酶基因 PTPN2 的缺失。
Nat Genet. 2010 Jun;42(6):530-5. doi: 10.1038/ng.587. Epub 2010 May 16.
7
STATs in cancer inflammation and immunity: a leading role for STAT3.信号转导和转录激活因子在癌症炎症与免疫中的作用：信号转导和转录激活因子3起主导作用
Nat Rev Cancer. 2009 Nov;9(11):798-809. doi: 10.1038/nrc2734.
8
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila.果蝇中JAK/STAT信号通路组分的全基因组RNA干扰分析。
Genes Dev. 2005 Aug 15;19(16):1861-70. doi: 10.1101/gad.1320705. Epub 2005 Jul 29.
9
Identification of a nuclear Stat1 protein tyrosine phosphatase.一种核 Stat1 蛋白酪氨酸磷酸酶的鉴定。
Mol Cell Biol. 2002 Aug;22(16):5662-8. doi: 10.1128/MCB.22.16.5662-5668.2002.

酪氨酸磷酸酶作为乳腺癌中STAT信号负调控因子的作用：新发现与未来展望

On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives.

作者信息

Tremblay Michel L

出版信息

Breast Cancer Res. 2013 Jul 31;15(4):312. doi: 10.1186/bcr3437.

DOI:10.1186/bcr3437
PMID:23905670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3978625/
Abstract

The increasing importance of signal transducer and activator of transcription 3 (STAT3) expression in human cancers has led several laboratories to examine in detail the expression of one of its major negative regulators in oncogenesis--the T-cell protein tyrosine phosphatase, nonreceptor type 2 (PTPN2). A recent paper by Shields and colleagues points to the associate depletion of PTPN2 in STAT3-positive breast cancers. We examine these findings and reflect on the mechanism of action of PTPN2 and the consequences of its modulation for STAT3 downstream signaling.

摘要

信号转导与转录激活因子3（STAT3）在人类癌症中的重要性日益增加，促使多个实验室详细研究其在肿瘤发生过程中的主要负调控因子之一——非受体型2 T细胞蛋白酪氨酸磷酸酶（PTPN2）的表达。Shields及其同事最近发表的一篇论文指出，STAT3阳性乳腺癌中PTPN2会伴随性缺失。我们研究了这些发现，并思考了PTPN2的作用机制及其调节对STAT3下游信号传导的影响。