酪氨酸磷酸酶作为乳腺癌中STAT信号负调控因子的作用：新发现与未来展望
On the role of tyrosine phosphatases as negative regulators of STAT signaling in breast cancers: new findings and future perspectives.
作者信息
Tremblay Michel L
出版信息
Breast Cancer Res. 2013 Jul 31;15(4):312. doi: 10.1186/bcr3437.
Abstract
The increasing importance of signal transducer and activator of transcription 3 (STAT3) expression in human cancers has led several laboratories to examine in detail the expression of one of its major negative regulators in oncogenesis--the T-cell protein tyrosine phosphatase, nonreceptor type 2 (PTPN2). A recent paper by Shields and colleagues points to the associate depletion of PTPN2 in STAT3-positive breast cancers. We examine these findings and reflect on the mechanism of action of PTPN2 and the consequences of its modulation for STAT3 downstream signaling.
摘要
信号转导与转录激活因子3（STAT3）在人类癌症中的重要性日益增加，促使多个实验室详细研究其在肿瘤发生过程中的主要负调控因子之一——非受体型2 T细胞蛋白酪氨酸磷酸酶（PTPN2）的表达。Shields及其同事最近发表的一篇论文指出，STAT3阳性乳腺癌中PTPN2会伴随性缺失。我们研究了这些发现，并思考了PTPN2的作用机制及其调节对STAT3下游信号传导的影响。
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