Halse Stacey, Pizzirani Stefano, Parry Nicola M A, Burgess Kristine E
Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA, 01536, USA.
Vet Ophthalmol. 2014 May;17(3):221-7. doi: 10.1111/vop.12084. Epub 2013 Aug 1.
A 3-year-old Marwari mare was presented for evaluation of an irregular, reddish mass protruding from behind the right third eyelid. The mass appeared to arise at the ventral limbal area, involved the perilimbal bulbar conjunctiva and widely extended into corneal tissue. No other ocular or systemic abnormalities were detected at the time of presentation. The mass was surgically removed by lamellar keratectomy, with defocused CO(2) laser used as adjunctive therapy to treat the surgical exposed area and its surroundings. Histopathologic evaluation showed sheets of densely packed, well-differentiated neoplastic mast cells separated by fibrovascular connective tissue. Nuclear staining for Ki-67 was performed, and an average of 370 cells were positive per 1000 counted cells. Two months postoperatively, the surgical site was filled with flat fibrovascular and pigmented tissue, while the surrounding cornea was transparent with no superficial vascularization around the fibrotic scar. Thirty-two months after treatment, no recurrence of the neoplasia was reported.
一匹3岁的马尔瓦里母马因右第三眼睑后方突出一个不规则的红色肿物前来评估。肿物似乎起源于角膜缘腹侧区域，累及角膜缘球结膜并广泛延伸至角膜组织。就诊时未发现其他眼部或全身异常。通过板层角膜切除术手术切除肿物，使用散焦二氧化碳激光作为辅助治疗，以治疗手术暴露区域及其周围组织。组织病理学评估显示，密集排列、分化良好的肿瘤性肥大细胞片被纤维血管结缔组织分隔。进行了Ki-67核染色，每1000个计数细胞中平均有370个细胞呈阳性。术后两个月，手术部位充满扁平的纤维血管和色素沉着组织，而周围角膜透明，纤维化瘢痕周围无浅层血管化。治疗32个月后，未报告肿瘤复发。
