Pinn Toby L, Cushing Tim, Valentino Lorie Moore, Koch Seth A
Cornell University, College of Veterinary Medicine, Equine and Farm Animal Hospital, Ithaca, New York 14853-6401, USA.
Vet Ophthalmol. 2011 May;14(3):200-4. doi: 10.1111/j.1463-5224.2010.00856.x.
A 15-year-old gray Arabian gelding presented for evaluation of a lateral limbal mass extending across approximately 30% of the cornea. Grossly, the raised mass appeared nonpigmented, smooth, and irregular in shape, with an area of central necrosis and serosanguinous discharge. The mass was removed via lamellar keratectomy and histopathologic evaluation revealed features characteristic of hemangiosarcoma (HSA), including irregular vascular channels lined by a plump spindle cell population. Immunohistochemistry results showed that the neoplastic cells lining the vascular channels present diffuse and strong cytoplasmic reaction with von Willebrand Factor and the perivascular spindle cells exhibit moderate cytoplasmic reaction for smooth muscle actin. A lack of cytokeratin staining definitively excluded a diagnosis of atypical squamous cell carcinoma. Smooth muscle actin staining of the perivascular cells adjacent to the neoplastic endothelial cells is not a feature commonly described in HSA and has not been reported in previous cases of equine HSA. The horse remained in good health 21 months postkeratectomy and has exceeded the survival time of previously documented equine ocular HSA cases where more extreme surgical excision was performed.
一匹15岁的灰色阿拉伯种公马前来就诊，评估其角膜缘外侧肿物，该肿物横跨角膜约30%。大体上，隆起的肿物无色素沉着，表面光滑，形状不规则，中央有坏死区并伴有血性浆液性分泌物。通过板层角膜切除术切除肿物，组织病理学评估显示具有血管肉瘤（HSA）的特征，包括由丰满的梭形细胞构成的不规则血管通道。免疫组织化学结果显示，血管通道内衬的肿瘤细胞对血管性血友病因子呈弥漫性强细胞质反应，血管周围的梭形细胞对平滑肌肌动蛋白呈中度细胞质反应。细胞角蛋白染色阴性明确排除了非典型鳞状细胞癌的诊断。肿瘤性内皮细胞邻近的血管周围细胞平滑肌肌动蛋白染色是HSA中不常描述的特征，此前马眼部HSA病例中未见报道。角膜切除术后21个月，这匹马健康状况良好，其存活时间超过了之前记录的接受更激进手术切除的马眼部HSA病例。
