Centro de Investigação em Química, Department of Chemistry and Biochemistry, University of Porto, Rua do Campo Alegre, s/n, 4169-007 Porto, Portugal.
J Phys Chem B. 2013 Aug 15;117(32):9400-11. doi: 10.1021/jp400127k. Epub 2013 Aug 1.
Synthetic amino acid-based surfactants possess versatile aggregation properties and are typically more biocompatible and biodegradable than surfactants with conventional headgroups. This opens the possibility of a myriad of specialty applications, namely in pharmaceutics, cosmetics, biomedicine, and nanotemplating chemistry. In this work, we have investigated the interfacial and self-assembling properties in aqueous medium of novel double-chained lysine-based surfactants, with particular focus on the behavior of the dodecyl derivative, 12Lys12. Upon cooling from dilute isotropic micellar solutions, this surfactant crystallizes into micrometer-sized tubular structures that induce gelation of the system. The tubules have been characterized in terms of morphology, assembly process, thermal behavior, and stability, by using differential scanning calorimetry, light and scanning electron microscopy, and deuterium NMR. Possible mechanisms for tubule assembly are discussed, on the basis of surfactant molecular shape, H-bonding and electrostatic interactions, and chirality effects.
基于合成氨基酸的表面活性剂具有多功能的聚集性质，通常比具有传统头基的表面活性剂更具有生物相容性和可生物降解性。这为各种特殊应用提供了可能性，特别是在药剂学、化妆品、生物医学和纳米模板化学领域。在这项工作中，我们研究了新型双链赖氨酸基表面活性剂在水介质中的界面和自组装性质，特别关注十二烷基衍生物 12Lys12 的行为。当从稀各向同性胶束溶液冷却时，这种表面活性剂结晶成微米大小的管状结构，诱导体系凝胶化。通过差示扫描量热法、光和扫描电子显微镜以及氘 NMR，对管状结构的形态、组装过程、热行为和稳定性进行了表征。基于表面活性剂分子形状、氢键和静电相互作用以及手性效应，讨论了管状组装的可能机制。
