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基于ε-酰化赖氨酸的衍生物的设计、合成及性能研究

Design, synthesis and properties investigation of -acylation lysine based derivatives.

作者信息

Shi Ting-Ting, Fang Zheng, Zeng Wen-Bo, Yang Zhao, He Wei, Guo Kai

机构信息

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University Nanjing 211816 P. R. China

Department of Chemistry, Bengbu Medical College 233030 P. R. China.

出版信息

RSC Adv. 2019 Mar 6;9(13):7587-7593. doi: 10.1039/c9ra00213h. eCollection 2019 Mar 1.

DOI:10.1039/c9ra00213h
PMID:35519941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9061198/
Abstract

Amino acid-based compounds have attracted attention as environmentally friendly bio-based materials. Our group has recently developed a novel family of -acylation lysine based derivatives. We introduced long chain acyl groups at the position selectively by a new synthetic route that avoided the process of amino protection and deprotection. Sodium -octanamide lysine (C8), sodium -capramide lysine (C10) and sodium -lauramide lysine (C12) can self-assemble into vesicles spontaneously. As a result, not only do they have potential in drug delivery system but also they may be used as bio-based surfactants applied in cosmetics and other industries.

摘要

氨基酸基化合物作为环境友好型生物基材料受到了关注。我们的团队最近开发了一种新型的基于N-酰化赖氨酸的衍生物家族。我们通过一种新的合成路线在N-位选择性地引入了长链酰基，该路线避免了氨基保护和脱保护过程。N-辛酰胺赖氨酸钠（C8）、N-癸酰胺赖氨酸钠（C10）和N-月桂酰胺赖氨酸钠（C12）可以自发地自组装成囊泡。因此，它们不仅在药物递送系统中具有潜力，而且还可以用作应用于化妆品和其他行业的生物基表面活性剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/6a3c5db0da8d/c9ra00213h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/2afb0d69ec3b/c9ra00213h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/1558d49c21e3/c9ra00213h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/3090225e30f2/c9ra00213h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/f6248648b604/c9ra00213h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/6131970ce47c/c9ra00213h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/62a624d5bc8d/c9ra00213h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/ed95fe821c17/c9ra00213h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/2d595132c7ba/c9ra00213h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/6a3c5db0da8d/c9ra00213h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/2afb0d69ec3b/c9ra00213h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/1558d49c21e3/c9ra00213h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/3090225e30f2/c9ra00213h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/f6248648b604/c9ra00213h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/6131970ce47c/c9ra00213h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/62a624d5bc8d/c9ra00213h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/ed95fe821c17/c9ra00213h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/2d595132c7ba/c9ra00213h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dd2/9061198/6a3c5db0da8d/c9ra00213h-f8.jpg

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