Liu Xiao-Qing, Mai Jin-Zhuang, Gao Xiang-Min, Wu Yong, Nie Zhi-Qiang, Ou Yan-Qiu, Chen Ji-Mei, Zhuang Jian
Guangdong Academy of Medical Sciences, Epidemiology Division, Department of Cardiac Surgery, Guangdong General Hospital, Guangdong Cardiovascular Institute, Guangzhou 510080, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Apr;41(4):337-40.
To summarize prevalence rate and region distribution of congenital heart disease (CHD) in 12-month-old and younger infants among four regions of Guangdong province, China.
Data from Guangdong CHD monitoring network including 34 monitoring units covering different geographic regions were analyzed. Professional training on screening and diagnosing CHD was provided to each work group member to improve the diagnosis level. CHD infants under or aged 12 months detected in the monitoring unit were included. CHD was diagnosed by fetus and infants echocardiography.
From July 2004 to December 2010, 383 281 perinatal were registered and 3263 cases of CHD were detected in the 34 member units of Guangdong CHD monitoring network [total prevalence rate of CHD: 0.851% (3263/383 281), male prevalence rate: 0.868% (1799/207 347), female prevalence rate:0.828% (1456/175 843)].Stillbirth CHD prevalence rate was significantly higher than livebirth CHD prevalence rate [10.627% (676/6361) vs. 0.686% (2587/376 920), P < 0.01]. The total prevalence of CHD was significantly higher in Pearl River Delta region [0.906% (2826/311 823)] than in other regions [0.611% (437/71 458), P < 0.01]. Ventricular septal defect [39.93% (1033/2587) in livebirth] was the most dominant CHD, followed by patent ductus arteriosus [29.84% (772/2587)] and secundum atrial septal defect [13.76% (356/2587)].
The present data indicate that the prevalence of CHD in Guangdong is at the medium-upper level of the country associated with high stillbirth rate. The dominant type of CHD is ventricular septal defect. CHD prevalence is higher in the Pearl River Delta region than in other regions.
总结中国广东省四个地区12月龄及以下婴儿先天性心脏病（CHD）的患病率及地区分布情况。
分析来自广东省CHD监测网络的数据，该网络包括34个覆盖不同地理区域的监测单位。对每个工作组成员进行CHD筛查和诊断的专业培训，以提高诊断水平。纳入监测单位中检测出的12月龄及以下的CHD婴儿。通过胎儿和婴儿超声心动图诊断CHD。
2004年7月至2010年12月，广东省CHD监测网络的34个成员单位共登记围产儿383281例，检测出CHD患儿3263例[CHD总患病率：0.851%（3263/383281），男性患病率：0.868%（1799/207347），女性患病率：0.828%（1456/175843）]。死产儿CHD患病率显著高于活产儿CHD患病率[10.627%（676/6361）对0.686%（2587/376920），P<0.01]。珠江三角洲地区CHD总患病率[0.906%（2826/311823）]显著高于其他地区[0.611%（437/71458），P<0.01]。室间隔缺损[活产儿中占39.93%（1033/2587）]是最主要的CHD类型，其次是动脉导管未闭[占29.84%（772/2587）]和继发孔型房间隔缺损[占13.76%（356/2587）]。
目前的数据表明，广东省CHD患病率处于全国中上等水平，且死产率较高。CHD的主要类型是室间隔缺损。珠江三角洲地区CHD患病率高于其他地区。
