Kaplan H J, Streilein J W, Stevens T R
J Immunol. 1975 Sep;115(3):805-10.
The mechanism by which the anterior chamber of the eye extends immunologic privilege to allogeneic donor tissues has been studied in inbred rats. Inoculation of allogeneic lymphoid cells into the anterior chamber demonstrated that although the site lacks a lymphatic drainage, the afferent limb of the immunologic reflex arc is intact because the recipient can recognize and mount a specific immune response. In addition, host immunity was able to express itself within the anterior chamber when induced systemically, indicating that the efferent limb of the reflex arc is also intact. Therefore, it is suggested that the unique immunologic features of the anterior chamber may result from the obligate intravenous presentation of graft antigen to the host's systemic immunologic apparatus, a route that prejudices the host's response in the direction of tolerance and/or enhancement rather than cell-mediated, tissue destructive immunity.
眼睛前房将免疫赦免赋予同种异体供体组织的机制已在近交系大鼠中进行了研究。将同种异体淋巴细胞接种到前房表明，尽管该部位缺乏淋巴引流，但免疫反射弧的传入支是完整的，因为受体能够识别并引发特异性免疫反应。此外，当全身诱导时，宿主免疫能够在前房内表现出来，这表明反射弧的传出支也是完整的。因此，有人提出，前房独特的免疫特征可能是由于移植抗原必须通过静脉呈递给宿主的全身免疫系统，这种途径使宿主的反应倾向于耐受和/或增强，而不是细胞介导的组织破坏性免疫。
