Kaplan H J, Streilein J W
J Immunol. 1977 Mar;118(3):809-14.
The immunizing abilities of alloantigens placed within the anterior chamber of the eye have been studied in inbred rats. Although intracameral inoculation of F1 hybrid lymphocytes into parental strain recipients elicited both cell- and antibody-mediated immunity, a delimited interval was identified postinoculation during which the systemic cell-mediated immune response was suppressed as indicated by prolonged acceptance of orthotopic skin allografts. The prompt appearance of hemagglutinating antibodies in the serum of immunized rats followed a time course which coincided with the suppression of cell-mediated immunity and suggested that the two events are casually related. Since exposure to allogeneic antigens on lymphoid cells via the anterior chamber elicits a transient suppression in cell-mediated immunity, where humoral immunity is preserved, the phenomenon resembles immune deviation.
已在近交系大鼠中研究了置于眼前房内的同种异体抗原的免疫能力。尽管将F1杂种淋巴细胞前房内接种到亲本品系受体中可引发细胞介导免疫和抗体介导免疫，但接种后确定了一个限定的间隔期，在此期间，原位皮肤同种异体移植的长期存活表明全身细胞介导免疫反应受到抑制。免疫大鼠血清中血凝抗体的迅速出现遵循的时间进程与细胞介导免疫的抑制相吻合，提示这两个事件存在因果关系。由于通过前房接触淋巴细胞上的同种异体抗原会引发细胞介导免疫的短暂抑制，而体液免疫得以保留，这种现象类似于免疫偏离。
