Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Thromb Res. 2013 Aug;132(2):227-33. doi: 10.1016/j.thromres.2013.07.007. Epub 2013 Jul 30.
Single nucleotide polymorphisms (SNPs) within the platelet endothelial cell adhesion molecule-1 (PECAM-1) gene have been proposed as predisposing factors for myocardial infarction (MI) but published reports have given conflicting findings.
The present study aimed to clarify the association between SNPs in PECAM-1 and MI using a meta-analysis of published studies.
Medline, HuGE Navigator and SCOPUS Library databases were searched to identify case-control studies which examined the association of SNPs in PECAM-1 and MI. Data were extracted using standardized methods. Combined odds ratios (OR) with 95% confidence intervals (CI) for the association of SNPs with MI were calculated using a random effect approach and under additive, dominant and recessive models of inheritance.
A total of 7 studies comprising 3886 cases and 4097 controls fulfilled the inclusion criteria. Three SNPs in PECAM-1 were investigated, namely rs668 (Leu125Val), rs12953 (Ser563Asn) and rs1131012 (Arg670Gly). The GG genotype of rs1131012 was associated with a reduced risk of MI under a recessive (OR: 0.81; 95%CI: 0.69-0.94; p=0.010), but not additive and dominant models (p>0.05). This association was robust in sensitivity analyses and not subject to heterogeneity. No significant association was detected between rs668 and rs12953 with MI under any of the inheritance models.
The results of the current meta-analysis suggest that homozygous polymorphic genotype (GG) of the rs1131012 SNP may confer protection against MI. The impact of this variant on the expression and function of PECAM-1 needs to be elucidated in future investigations.
血小板内皮细胞黏附分子-1（PECAM-1）基因中的单核苷酸多态性（SNPs）被认为是心肌梗死（MI）的易患因素，但已发表的报告得出的结果相互矛盾。
本研究旨在通过对已发表研究的荟萃分析，阐明 PECAM-1 中的 SNPs 与 MI 之间的关系。
通过检索 Medline、HuGE Navigator 和 SCOPUS 图书馆数据库，确定了检查 PECAM-1 中 SNPs 与 MI 之间关联的病例对照研究。使用标准化方法提取数据。使用随机效应方法，在加性、显性和隐性遗传模型下，计算与 SNPs 与 MI 关联的合并比值比（OR）及其 95%置信区间（CI）。
共有 7 项研究符合纳入标准，共纳入 3886 例病例和 4097 例对照。共研究了 PECAM-1 中的 3 个 SNPs，即 rs668（Leu125Val）、rs12953（Ser563Asn）和 rs1131012（Arg670Gly）。在隐性遗传模型下，rs1131012 的 GG 基因型与 MI 的风险降低相关（OR：0.81；95%CI：0.69-0.94；p=0.010），但在加性和显性遗传模型下不相关（p>0.05）。在敏感性分析中，该关联是稳健的，且无异质性。在任何遗传模型下，rs668 和 rs12953 与 MI 之间均未检测到显著关联。
本荟萃分析的结果表明，rs1131012 中的纯合多态基因型（GG）可能对 MI 具有保护作用。该变异对 PECAM-1 的表达和功能的影响需要在未来的研究中阐明。
